| CB/CC diffuse lymphoma: a distinct subtype of non-Hodgkin's lymphoma? A study of 1593 patients from a Danish population-based registry. Danish LYFO Study Group. | |
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MedLine Citation:
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PMID: 9209635 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Between 1983 and 1993, 3165 cases of non-Hodgkin's lymphoma (NHL) were reported to the West Danish Lymphoma Registry (LYFO). Out of these, 148 (4.7%) were of the CB/CC diffuse subtype according to the Kiel classification. However, in the new European-American NHL consensus classification (REAL, 1994), CB/CC diffuse lymphoma was categorized as a provisional subtype only. In the LYFO material, death-probability curves show a significantly shorter survival in CB/CC diffuse than in CB/CC follicular. In order to detect further possible differences between CB/CC diffuse and other NHL subtypes, a number of clinical parameters at presentation were analyzed in a subset of five types of lymphoma. This subset included 148 cases of CB/CC diffuse, 435 cases of CB/CC follicular, 667 cases of CB diffuse, 202 cases of CC diffuse, and 131 cases of peripheral T-cell lymphoma. Using logistic regression analysis, significant differences could be demonstrated between CB/CC diffuse and the four other subtypes as regards sex ratio, age distribution, and sites of both nodal and extranodal involvement. These findings indicate that CB/CC diffuse has a distinct clinical phenotype and imply the existence of real biological differences between CB/CC diffuse and other subtypes of lymphoma. |
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Authors:
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L Munksgaard; B E Christensen; H Brincker; N T Pedersen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of oncology : official journal of the European Society for Medical Oncology / ESMO Volume: 8 Suppl 2 ISSN: 0923-7534 ISO Abbreviation: Ann. Oncol. Publication Date: 1997 |
Date Detail:
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Created Date: 1997-09-05 Completed Date: 1997-09-05 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007735 Medline TA: Ann Oncol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 25-8 Citation Subset: IM |
Affiliation:
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Department of Hematology, Odense University Hospital, Denmark. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Cross-Sectional Studies Denmark Diagnosis, Differential Female Humans Logistic Models Lymphoma, Non-Hodgkin / pathology* Male Middle Aged Phenotype Registries Regression Analysis |
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