Document Detail

The diffuse endocrine system and derived tumours. Histological and histochemical characteristics.
MedLine Citation:
PMID:  6179119     Owner:  NLM     Status:  MEDLINE    
The Diffuse Endocrine System, to which the so-called APUD (Amine Precursor Uptake and Decarboxylation) cells do belong, gives rise to a group of tumours which may or not secrete amines and/or polypeptide hormones: carcinoids (argentaffinomas, argentaffin or Kultschitzky cell carcinomas). Foregut carcinoids are predominantly of B type (trabecular), argyrophilic, or non-reactive (in about 70% of cases) to silver impregnation. Midgut tumours are generally of A type (insular); more than 80% of them are argentaffinic. Hindgut derived carcinoids are primarily of mixed type; nearly 70% are non-reactive to silver stains. From a cytological standpoint all types may be build up of either small-round, spindle-shaped, polyhedral or cuboidal cells. From a functional point-of-view, the cells are either clear and immature, non-reducing or exhausted. Accordingly, the diagnosis cannot be based alone on silver impregnation or other histochemical methods.
L J van Bogaert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta histochemica     Volume:  70     ISSN:  0065-1281     ISO Abbreviation:  Acta Histochem.     Publication Date:  1982  
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  122-9     Citation Subset:  IM    
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MeSH Terms
APUD Cells / cytology*
Apudoma / pathology*
Breast Neoplasms / pathology
Carcinoid Tumor / pathology*
Genital Neoplasms, Female / pathology
Intestinal Neoplasms / pathology
Staining and Labeling

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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