Document Detail

The differing embryonic origins of retinal and uveal (iris/ciliary body and choroid) melanosomes are mirrored by their phospholipid composition.
MedLine Citation:
PMID:  17250549     Owner:  NLM     Status:  MEDLINE    
The phospholipids present in uveal (iris/ciliary body and choroid) and retinal bovine ocular melanosomes were identified using mass spectrometry. Similar phospholipid content is found for the two types of uveal melanosome, with sphingomyelin being the major species. Significant differences are found between the uveal and retinal melanosome. Glycerophosphoethanolamine (GPEtn) is the major species in the retinal pigment epithelium (RPE); 93% of the GPEtn contain polyunsaturated fatty acids, notably docosahexanoic acid and arachidonic acid, in the sn-2 position. RPE melanosomes also contain detectable quantities of glycerophosphoserine and glycerophosphate; these species were not detected in the uveal samples. While the structural and functional roles of melanosomal lipids largely remain to be determined, these different lipid compositions reported herein offer new insights into the roles of melanosomes in the different ocular tissues.
Weslyn C Ward; John D Simon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  20     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-25     Completed Date:  2007-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  61-9     Citation Subset:  IM    
Department of Chemistry, Duke University, Durham, NC, USA.
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MeSH Terms
Choroid / chemistry,  embryology
Ciliary Body / chemistry,  embryology
Glycerophospholipids / analysis,  chemistry
Iris / chemistry,  embryology,  ultrastructure
Mass Spectrometry
Melanosomes / chemistry*,  ultrastructure
Retina / chemistry*,  embryology*
Sphingomyelins / analysis,  chemistry
Uvea / chemistry*,  embryology*
Reg. No./Substance:
0/Glycerophospholipids; 0/Sphingomyelins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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