| Antimutagenic; differentiation-inducing; and antioxidative effects of fragrant ingredients in Katsura-uri (Japanese pickling melon; Cucumis melo var. conomon). | |
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MedLine Citation:
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PMID: 20801232 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Six fragrant ingredients were identified in fully-ripened Katsura-uri (Japanese pickling melon; Cucumis melo var. conomon). Four of them were sulfur-containing compounds [methylthioacetic acid ethyl ester (MTAE), acetic acid 2-methylthio ethyl ester (AMTE), 3-methylthiopropionic acid ethyl ester (MTPE), and acetic acid 3-methylthio propyl ester (AMTP)]; and the others were benzyl acetate and eugenol. The newly identified MTAE and AMTP possessed antimutagenic activity as determined by their ability to inhibit the UV-induced mutation in repair-proficient E. coli B/r WP2. MTAE and MTPE (esters with thiocarbonic acid and alkyl alcohol) induced the differentiation of human colon cancer cells (RCM-1 cells), but AMTE and AMTP (esters with carbonic acid and thioalkyl alcohol) did not. A specific thioester motif containing a thiocarbonic acid and alkyl alcohol correlated with these compounds ability to induce differentiation. AMTE, MTPE, AMTP, and eugenol had higher oxygen radical absorbing capacity than the antioxidative vitamin, ascorbic acid. The quantity of MTPE, AMTP and eugenol increased 49-fold, >1175-fold and 11-fold, respectively, in the fully-ripened fruit as compared to the mid-ripened fruit. |
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Authors:
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Yasushi Nakamura; Shinpei Watanabe; Minami Kageyama; Keiko Shirota; Koji Shirota; Hisashi Amano; Tadahiro Kashimoto; Tomoaki Matsuo; Shigehisa Okamoto; Eun Young Park; Kenji Sato |
Publication Detail:
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Type: Journal Article Date: 2010-08-27 |
Journal Detail:
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Title: Mutation research Volume: 703 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 163-8 Citation Subset: IM |
Copyright Information:
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2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Shimogamo-Hangi, Sakyo, Kyoto 606-8522, Japan. yas@kpu.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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