Document Detail


The differential inhibitory effects of genistein on the growth of cervical cancer cells in vitro.
MedLine Citation:
PMID:  11583294     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The biological effect of genistein on cervical cancer was studied on two cervical cancer cell lines with different cellular characteristics. Here we report that genistein exhibits inhibitory effects on the growth of HeLa and ME-180 cells. The IC50 was 35 microM and 60 microM for HeLa and ME-180 cells, respectively. ME-180 cells showed obvious G2/M arrest with genistein treatment while most of the HeLa cells were accumulated in S phase. The underlying molecular mechanism was further elucidated by apoptosis analysis and expression levels of cell cycle regulatory proteins. Treatment of the cell lines with genistein also resulted in suppression of invasion through a surrogate membrane in a dose-dependent manner, particularly the HeLa cells. While the underlying mechanism needs to be further studied, the higher suppressive effect on invasion of HeLa cells, an adenocarcinoma cell line, are noteworthy. This in vitro observation may have clinical implication to improve the treatment of cervical adenocarcinoma.
Authors:
S Y Wang; K W Yang; Y T Hsu; C L Chang; Y C Yang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neoplasma     Volume:  48     ISSN:  0028-2685     ISO Abbreviation:  Neoplasma     Publication Date:  2001  
Date Detail:
Created Date:  2001-10-03     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0377266     Medline TA:  Neoplasma     Country:  Slovakia    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
Affiliation:
Department of Medical Research, Mackay Memorial Hospital, Taipei, Taiwan. eugene@ms2.mmh.org.tw
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy
Blotting, Western
Carcinoma, Squamous Cell / drug therapy
Cell Cycle / drug effects*
Female
Genistein / pharmacology*,  therapeutic use
Growth Inhibitors / pharmacology*,  therapeutic use
Hela Cells / drug effects
Humans
Inhibitory Concentration 50
Tumor Cells, Cultured / drug effects
Uterine Cervical Neoplasms / drug therapy*
Chemical
Reg. No./Substance:
0/Growth Inhibitors; 446-72-0/Genistein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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