| A differential equation model for functional mapping of a virus-cell dynamic system. | |
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MedLine Citation:
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PMID: 19685244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The dynamic pattern of viral load in a patient's body critically depends on the host's genes. For this reason, the identification of those genes responsible for virus dynamics, although difficult, is of fundamental importance to design an optimal drug therapy based on patients' genetic makeup. Here, we present a differential equation (DE) model for characterizing specific genes or quantitative trait loci (QTLs) that affect viral load trajectories within the framework of a dynamic system. The model is formulated with the principle of functional mapping, originally derived to map dynamic QTLs, and implemented with a Markov chain process. The DE-integrated model enhances the mathematical robustness of functional mapping, its quantitative prediction about the temporal pattern of genetic expression, and therefore its practical utilization and effectiveness for gene discovery in clinical settings. The model was used to analyze simulated data for viral dynamics, aimed to investigate its statistical properties and validate its usefulness. With an increasing availability of genetic polymorphic data, the model will have great implications for probing the molecular genetic mechanism of virus dynamics and disease progression. |
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Authors:
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Jiangtao Luo; William W Hager; Rongling Wu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-08-15 |
Journal Detail:
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Title: Journal of mathematical biology Volume: 61 ISSN: 1432-1416 ISO Abbreviation: J Math Biol Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-05-05 Completed Date: 2010-07-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7502105 Medline TA: J Math Biol Country: Germany |
Other Details:
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Languages: eng Pagination: 1-15 Citation Subset: IM |
Affiliation:
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Department of Mathematics, University of Florida, Gainesville, FL 32611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Chromosome Mapping* Computer Simulation / statistics & numerical data Humans Models, Genetic* Models, Statistical Quantitative Trait Loci* Viral Load / genetics* Virus Diseases / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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0540745//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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