Document Detail

The differential effects of prostaglandin E1 and nitroglycerin on regional cerebral oxygenation in anesthetized patients.
MedLine Citation:
PMID:  9356099     Owner:  NLM     Status:  MEDLINE    
IMPLICATIONS: The cerebrovascular effects of vasodilators used for induced hypotension are not fully understood. In this study, we used near infrared spectrometry and jugular oxygen saturation measurement to assess the effects of prostaglandin E1 and nitroglycerin on cerebral perfusion. We found that nitroglycerin and prostaglandin E1 increase cerebral oxygen saturation as measured by near infrared spectrometry, but with different time courses. This information will hopefully help anesthesiologists to better maintain adequate regional cerebral oxygenation.
Y Kadoi; S Saito; T Morita; T Imai; H Kawahara; N Fujita; F Goto
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  85     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-11-28     Completed Date:  1997-11-28     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1054-9     Citation Subset:  AIM; IM    
Department of Anesthesiology and Reanimatology, Gunma University School of Medicine, Japan.
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MeSH Terms
Alprostadil / therapeutic use*
Anesthesia, General / methods*
Blood Pressure / drug effects
Brain / blood supply*,  metabolism*
Electron Transport Complex IV / metabolism
Hemoglobins / metabolism
Infusions, Intravenous
Middle Aged
Nitroglycerin / therapeutic use*
Oxygen Consumption / drug effects*
Oxyhemoglobins / metabolism
Spectroscopy, Near-Infrared
Thoracic Surgical Procedures
Vasodilator Agents / therapeutic use*
Reg. No./Substance:
0/Hemoglobins; 0/Oxyhemoglobins; 0/Vasodilator Agents; 55-63-0/Nitroglycerin; 745-65-3/Alprostadil; 9008-02-0/deoxyhemoglobin; EC Transport Complex IV
Comment In:
Anesth Analg. 1998 Jun;86(6):1338-9   [PMID:  9620538 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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