Document Detail

The differential effects of intravenously administered 8-OH-DPAT on operant food intake in satiated and food-deprived pigs are mediated by central 5-HT(1A) receptors.
MedLine Citation:
PMID:  11399315     Owner:  NLM     Status:  MEDLINE    
It has previously been shown that the intravenous administration of the 5-HT(1A) receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), increases food intake in satiated pigs and decreases food intake in fasted pigs. The present experiments were conducted to investigate the effects of central administration of the 5-HT(1A) receptor antagonist, N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-N-2-pyridinyl-cyclohexane carbox-amide maleate (WAY 100635), on the stimulant and depressant effects of 8-OH-DPAT on operant food intake in satiated and hungry pigs. In Experiment 1, 8-OH-DPAT (25 microg/kg) produced an increase in operant feeding during the first 30 min following intravenous administration to satiated pigs. The 8-OH-DPAT-induced hyperphagia was completely abolished by pretreatment with WAY 100635 (0.3 mg) administered by intracerebroventricular injection. In Experiment 2, 8-OH-DPAT (25 microg/kg) administered intravenously 15 min prior to the onset of feeding in pigs that had been fasted for 22.5 h produced a decrease in operant food intake, which was most apparent during the first 30 min of the feeding period. The hypophagic effect was completely abolished by pretreatment with WAY 100635 (0.3 mg icv) administered 30 min before the start of the feeding period. In both experiments, WAY 100635 (0.3 mg icv) did not have any significant effects on feeding. The results of the present study extend previous results in the pig and show that both the hyperphagic and the hypophagic effects of 8-OH-DPAT in satiated and fasted pigs, respectively, are mediated by central 5-HT(1A) receptors.
I S Ebenezer; S V Vellucci; R F Parrott
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Physiology & behavior     Volume:  73     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-06-11     Completed Date:  2001-08-09     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  223-7     Citation Subset:  IM    
Department of Neurobiology, Babraham Institute, Cambridge CB2 4AT, UK.
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MeSH Terms
8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology*
Brain / drug effects
Conditioning, Operant / drug effects*
Eating / drug effects*
Fasting / psychology*
Hunger / drug effects*
Injections, Intravenous
Injections, Intraventricular
Piperazines / pharmacology
Pyridines / pharmacology
Receptors, Serotonin / drug effects*
Receptors, Serotonin, 5-HT1
Satiety Response / drug effects*
Reg. No./Substance:
0/Piperazines; 0/Pyridines; 0/Receptors, Serotonin; 0/Receptors, Serotonin, 5-HT1; 146714-97-8/WAY 100635; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin

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