| The differential diagnosis of familial lentiginosis syndromes. | |
| | |
MedLine Citation:
|
PMID: 21538076 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Cutaneous markers of systemic disease are vital for clinicians to recognize. This chapter outlines familial lentiginosis syndromes that include Peutz-Jeghers syndrome, Carney Complex, the PTEN hamartomatous syndromes, and LEOPARD/Noonan syndrome. The inheritance of these syndromes is autosomal dominant; they also share characteristic skin findings that offer a clue to their recognition and treatment. We will discuss the clinical presentation of these disorders, with a focus on the dermatological manifestations, and will provide an update on the molecular mechanisms involved. Recognition of cutaneous markers associated with these rare familial cancer syndromes provides the opportunity to pursue early surveillance for malignancies, as well as genetic counseling. |
| | |
Authors:
|
Maya B Lodish; Constantine A Stratakis |
Related Documents
:
|
15467336 - Pulmonary hemorrhage complicating a typical hemolytic-uremic syndrome. 2302866 - Dense intramembranous deposit disease: a clinical comparison of histological subtypes. 2714026 - Crescentic glomerulonephritis in behçet's syndrome--results of therapy and review of t... 10975316 - Clinical and radiological features in four adolescents with nutcracker syndrome. 22232386 - Effects of sampling context on spontaneous expressive language in males with fragile x ... 342696 - A 'new' syndrome of mental retardation with characteristic facies and brachyphalangy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-3 |
Journal Detail:
|
Title: Familial cancer Volume: - ISSN: 1573-7292 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100898211 Medline TA: Fam Cancer Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Section on Endocrinology and Genetics, Program on Developmental Endocrinology Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, and Pediatric Endocrinology Inter-Institute Training Program, National Institutes of Health, Building 10, CRC Room 1-3330, 10 Center Drive, MSC 1103, Bethesda, MD, 20892, USA, lodishma@mail.nih.gov. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Challenge of Asthma in Minority Populations.
Next Document: Low penetrance hereditary retinoblastoma in a family: what should we consider in the genetic counsel...