Document Detail

The differential diagnosis between preeclamptic toxemia and glomerulonephritis in patients with proteinuria during pregnancy.
MedLine Citation:
PMID:  1005033     Owner:  NLM     Status:  MEDLINE    
The renal biopsies from 123 patients who presented with proteinuria during pregnancy have been reviewed. Forty-seven showed glomerulonephritis that could be diagnosed on morphological grounds or on a clear-cut history of urine abnormalities before pregnancy. Fifty of the remaining 76 had been followed after pregnancy. In these 50 patients, a retrospective diagnosis of glomerulonephritis or preeclamptic toxemia was based on the persistence or disappearance of proteinuria and/or hematuria three or more months after pregnancy. Among 22 in whom a biopsy diagnosis of "pure" preeclamptic toxemia had been made, 19 showed disappearance of urine abnormalities after pregnancy, thus confirming the biopsy diagnosis. A retrospective analysis showed focal and segmental glomeris group but none in the preeclamptic toxemia group. Other differences could not be defined without quantitative evaluation; however, the glomeruli appeared to be more cellular in the glomerulonephritis group. The presence of IgA, IgG, IgM, Complement, and fibrin was not of value in distinguishing glomerulonephritis from preeclamptic toxemia.
P Kincaid-Smith; K F Fairley
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Perspectives in nephrology and hypertension     Volume:  5     ISSN:  0092-2900     ISO Abbreviation:  Perspect Nephrol Hypertens     Publication Date:  1976  
Date Detail:
Created Date:  1977-02-24     Completed Date:  1977-02-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0402144     Medline TA:  Perspect Nephrol Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  157-67     Citation Subset:  IM    
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MeSH Terms
Arteries / pathology
Diagnosis, Differential
Glomerulonephritis / complications,  diagnosis*
Kidney / blood supply,  pathology
Pre-Eclampsia / complications
Pregnancy Complications / diagnosis*,  pathology
Proteinuria / etiology*

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