Document Detail

The differential cardiovascular response to centrally administered carbachol seen in Brattleboro and normal Long-Evans rats.
MedLine Citation:
PMID:  3242998     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of centrally administered carbachol were examined in conscious Long-Evans (LE) and Brattleboro (DI) rats. Carbachol induced a long-lasting increase in blood pressure and a decrease in heart rate in LE rats, whereas in DI rats no bradycardia was observed and the pressor response was significantly less than that in Long-Evans rats. Intravenous vasopressin antagonist, d(CH2)5 Tyr(Me)AVP, significantly attenuated the pressor response and eliminated the bradycardic response to carbachol in LE rats. However, the pressor response to carbachol in DI rats was still significantly less than that in LE rats treated with vasopressin antagonist. Intravenous phentolamine partially inhibited the pressor response to carbachol in LE rats and completely eliminated it in DI rats. These results suggest that hypertensive response to i.c.v. carbachol in normal rats is mediated both by an increase in central sympathetic outflow and in circulating vasopressin. The bradycardia seems to be mediated mainly by an increase in circulating vasopressin.
Y Imai; S Sasaki; N Minami; Munakata; H Sekino; K Abe; K Yoshinaga
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  10 Suppl 1     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-30     Completed Date:  1989-05-30     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-30     Citation Subset:  IM    
Department of Medicine, Tohoku University School of Medicine, Sendai, Japan.
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MeSH Terms
Blood Pressure / drug effects*
Carbachol / administration & dosage,  pharmacology*
Heart Rate / drug effects*
Injections, Intraventricular
Rats, Brattleboro
Rats, Inbred Strains
Vasopressins / antagonists & inhibitors,  physiology*,  secretion
Reg. No./Substance:
11000-17-2/Vasopressins; 51-83-2/Carbachol

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