Document Detail


The different stages of synovitis: acute vs chronic, early vs late and non-erosive vs erosive.
MedLine Citation:
PMID:  15588969     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Rheumatoid arthritis is a systemic inflammatory disease that, by definition, can affect all parts of the human body, including severe complications such as uveitis/episcleritis and vasculitis of the heart, lungs, kidneys and the central and peripheral nervous systems. Its primary and by far the most common manifestations, however, affect the joints and are characterised by inflammatory reactions and activation of the synovial lining tissue and associated structures, the latter resulting in tenovaginitis and rheumatoid nodules. As all pathophysiological mechanisms are based on pathways that are inherent in the different components of a joint, it is necessary to examine the unique features of normal synovium prior to analysing disease-specific pathways. This chapter will therefore describe the physiological structure of the synovium and the inflammatory pathology of rheumatoid synovitis in early and chronic stages of the disease.
Authors:
Ingo H Tarner; Peter Härle; Ulf Müller-Ladner; Renate E Gay; Steffen Gay
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical rheumatology     Volume:  19     ISSN:  1521-6942     ISO Abbreviation:  Best Pract Res Clin Rheumatol     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-03-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101121149     Medline TA:  Best Pract Res Clin Rheumatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  19-35     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine I, University Hospital Regensburg, D-93042 Regensburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Arthritis, Rheumatoid / complications,  metabolism,  pathology*
Chemokines / metabolism
Chronic Disease
Early Diagnosis
Humans
Rheumatology / methods*
Synovial Membrane / metabolism,  pathology*
Synovitis / etiology,  metabolism,  pathology*
Chemical
Reg. No./Substance:
0/Chemokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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