| A different first choice drug in the medical management of patent ductus arteriosus: Oral paracetamol. | |
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MedLine Citation:
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PMID: 23205872 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background and Objectives: Patent ductus arteriosus (PDA) is a significant cause of morbidity and mortality in preterm infants. This case series was conducted to investigate the usefulness of paracetamol as a first choice for the treatment of PDA in preterm infants. Subjects and Methods: Preterm infants were prospectively enrolled. Treatment with oral paracetamol was started at a dose of 15 mg/kg every 6 h for 3 days, with echocardiographic evaluation performed at the end of the treatment and two days after the treatment. Serum paracetamol levels were also evaluated 24 h after the first dose to ensure the absorption and reaching the therapeutic level. Results: A total of 6 preterm infants were prospectively enrolled. Five infants with PDA were successfully treated with oral paracetamol. Only one patient did not respond to paracetamol treatment whereas another one received a second cure due to reopening of the ductus. Conclusion: Paracetamol may be a useful treatment option for the primer treatment of PDA in preterm infants. If paracetamol is shown to be effective in a large series, because of low risk of side effects, low cost and preparation is available in enteral form, it may be an advantageous alternative at PDA treatment. |
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Authors:
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Sadik Yurttutan; Mehmet Yekta Oncel; Sema Arayıcı; Nurdan Uras; Altug Nahide; Erdeve Omer; Dilmen Ugur |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-3 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Zekai Tahir Burak MaternityTeachingHospital, Division of Neonatology, Ankara, Turkey; |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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