Document Detail


A different first choice drug in the medical management of patent ductus arteriosus: Oral paracetamol.
MedLine Citation:
PMID:  23205872     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and Objectives: Patent ductus arteriosus (PDA) is a significant cause of morbidity and mortality in preterm infants. This case series was conducted to investigate the usefulness of paracetamol as a first choice for the treatment of PDA in preterm infants. Subjects and Methods: Preterm infants were prospectively enrolled. Treatment with oral paracetamol was started at a dose of 15 mg/kg every 6 h for 3 days, with echocardiographic evaluation performed at the end of the treatment and two days after the treatment. Serum paracetamol levels were also evaluated 24 h after the first dose to ensure the absorption and reaching the therapeutic level. Results: A total of 6 preterm infants were prospectively enrolled. Five infants with PDA were successfully treated with oral paracetamol. Only one patient did not respond to paracetamol treatment whereas another one received a second cure due to reopening of the ductus. Conclusion: Paracetamol may be a useful treatment option for the primer treatment of PDA in preterm infants. If paracetamol is shown to be effective in a large series, because of low risk of side effects, low cost and preparation is available in enteral form, it may be an advantageous alternative at PDA treatment.
Authors:
Sadik Yurttutan; Mehmet Yekta Oncel; Sema Arayıcı; Nurdan Uras; Altug Nahide; Erdeve Omer; Dilmen Ugur
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-3
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Zekai Tahir Burak MaternityTeachingHospital, Division of Neonatology, Ankara, Turkey;
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