| The different effects of leucine, isoleucine, and valine on systolic properties of the normal and septic isolated rat heart. | |
| | |
MedLine Citation:
|
PMID: 3982017 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Protein turnover in cardiac and skeletal muscle is affected by the provision of amino acids, particularly the branched chain amino acids (BCAA). The effect of each of the BCAA, valine, leucine, and isoleucine, on the systolic function of isolated normal or septic rat heart perfused as a Langendorff preparation was examined. Thirty normal control and 28 septic rats (cecal ligation and puncture) were perfused with either Krebs + 8.5 mM glucose or Krebs + 5.0 mM glucose and 3.5 mM valine, leucine, or isoleucine. Septic hearts perfused with Krebs + 8.5 mM glucose exhibited developed force (DF) and force velocity (dF/dt) levels which were reduced to an average of 45 and 50%, respectively, compared to normal controls, and improved by 35% during 60 min perfusion over measurements made at time zero. In normal hearts DF and dF/dt decreased significantly during perfusion with leucine (27%) and isoleucine (20%). In sepsis, perfusion with leucine and isoleucine resulted in a mild improvement in systolic function. However, valine was far less effective than leucine and isoleucine in maintaining systolic function in sepsis, due apparently to valine being a less efficient energy substrate for the cardiac muscle in a state of severe energy deficit. Thus, valine, leucine, and isoleucine seem to exert different effects on the systolic function of normal and septic isolated rat hearts. |
| | |
Authors:
|
L J Markovitz; Y Hasin; E J Dann; M S Gotsman; H R Freund |
Related Documents
:
|
12797597 - Functional effects of acute coronary occlusion and catecholinergic stimuli on the isola... 6807097 - Effects of lysine on bicarbonate and fluid absorption in the rat proximal tubule. 9068827 - Facility changes mediated by camp in the bovine anterior segment in vitro. 23462257 - Self-motion effects on hydrodynamic pressure sensing: part i. forward-backward motion. 16100177 - Stroke volume and pulse pressure variation for prediction of fluid responsiveness in pa... 16258027 - Vascular endothelial-derived semaphorin 3 inhibits sympathetic axon growth. |
Publication Detail:
|
Type: Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of surgical research Volume: 38 ISSN: 0022-4804 ISO Abbreviation: J. Surg. Res. Publication Date: 1985 Mar |
Date Detail:
|
Created Date: 1985-04-29 Completed Date: 1985-04-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 231-6 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Amino Acids, Branched-Chain
/
pharmacology* Animals Coronary Circulation / drug effects Infection / metabolism, physiopathology* Isoleucine / pharmacology Leucine / pharmacology Myocardial Contraction / drug effects* Perfusion Rats Systole / drug effects* Valine / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Amino Acids, Branched-Chain; 61-90-5/Leucine; 7004-03-7/Valine; 73-32-5/Isoleucine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Noninvasive measurement of femoral artery pressure for evaluating aortoiliac occlusive disease.
Next Document: The control of peritendinous adhesions using topical beta-aminopropionitrile base.