Document Detail

Racial/ethnic differences in bone mineral density among older women.
MedLine Citation:
PMID:  23143509     Owner:  NLM     Status:  MEDLINE    
The epidemiologic information regarding international differences in bone mineral density (BMD) in women is currently insufficient. We compared BMD in older women across five racial/ethnic groups in four countries. The femoral neck, total hip, and lumbar spine BMD were measured in women (aged 65-74 years) from the Study of Osteoporotic Fractures (SOF) (5,035 Caucasian women and 256 African American women in the US), the Tobago Women's Health Study (116 Afro-Caribbean women), the Ms Os Hong Kong Study (794 Hong Kong Chinese women) and the Namwon Study (1,377 South Korean women). BMD was corrected according to the cross-site calibration results for all scanners. When compared with US Caucasian women, the age adjusted mean BMD measurements at the hip sites were 21-31 % higher among Tobago Afro-Caribbean women and 13-23 % higher among African American women. The total hip and spine BMD values were 4-5 % lower among Hong Kong Chinese women and 4-7 % lower among South Korean women compared to US Caucasians. The femoral neck BMD was similar in Hong Kong Chinese women, but higher among South Korean women compared to US Caucasians. Current/past estrogen use was a significant contributing factor to the difference in BMD between US versus non-US women. Differences in body weight partially explained the difference in BMD between Asian versus non-Asian women. These findings show substantial racial/ethnic differences in BMD even within African or Asian origin individuals, and highlight the contributing role of body weight and estrogen use to the geographic and racial/ethnic variation in BMD.
Hae-Sung Nam; Sun-Seog Kweon; Jin-Su Choi; Joseph M Zmuda; P C Leung; Li-Yung Lui; Deanna D Hill; Alan L Patrick; Jane A Cauley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-10
Journal Detail:
Title:  Journal of bone and mineral metabolism     Volume:  31     ISSN:  1435-5604     ISO Abbreviation:  J. Bone Miner. Metab.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-07     Completed Date:  2013-08-14     Revised Date:  2014-08-05    
Medline Journal Info:
Nlm Unique ID:  9436705     Medline TA:  J Bone Miner Metab     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  190-8     Citation Subset:  IM    
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MeSH Terms
African Continental Ancestry Group / ethnology*
Aging / physiology
Asian Continental Ancestry Group / ethnology*
Body Weight
Bone Density / physiology*
European Continental Ancestry Group / ethnology*
Life Style
Grant Support
1R01 AR049439-01A1/AR/NIAMS NIH HHS; 2 R01 AG005394-22A1/AG/NIA NIH HHS; 2 R01 AG027574-22A1/AG/NIA NIH HHS; AG05394/AG/NIA NIH HHS; AG05407/AG/NIA NIH HHS; AR35582/AR/NIAMS NIH HHS; AR35583/AR/NIAMS NIH HHS; AR35584/AR/NIAMS NIH HHS; R01 AG005394/AG/NIA NIH HHS; R01 AG005407/AG/NIA NIH HHS; R01 AG027574/AG/NIA NIH HHS; R01 AG027576/AG/NIA NIH HHS; R01 AG027576-22/AG/NIA NIH HHS; R01 AR035582/AR/NIAMS NIH HHS; R01 AR035583/AR/NIAMS NIH HHS; R01 AR035584/AR/NIAMS NIH HHS; R01AG005407/AG/NIA NIH HHS

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