Document Detail


The differences of eosinophil- and neutrophil-related inflammation in elderly allergic and non-allergic chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  20858153     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a common disease in the elderly population and is characterized by airway inflammation. Whether it is a progressive condition resulting from allergic inflammation or a distinct condition involving a pathogen-induced reaction remains unclear.
OBJECTIVES: To determine the role of allergic inflammation in the pathogenesis of elderly COPD.
METHODS: A total of 63 elderly adults (21 mite-allergic COPD patients, 29 non-allergic COPD patients, and 13 normal controls) were recruited in this study. The serum-specific IgE for mites, level of interleukin-5 (IL-5), IL-8, leptin, adiponectin, regulated upon activation normal T cell expressed and secreted (RANTES), growth-related oncogene-α (GRO-α), vitamin E, and glutathione (GSH) were determined.
RESULTS: The serum levels of GRO-α in patients with COPD were higher in comparison to normal controls (105.8 ± 32.7 vs. 7.5 ± 7.5 pg/mL, p= .021). Compared to patients with non-allergic COPD, patients with mite allergies had a higher serum level of IL-8 (63.2 ± 12.6 vs. 35.0 ± 8.2 pg/mL, p= .022). Although both IL-5 and RANTES levels were increased in COPD patients, there were no significant differences between allergic and non-allergic COPD. There were also no differences in serum levels of leptin, adiponectin, vitamin E, and GSH between COPD patients and normal controls.
CONCLUSIONS: The increased serum levels of GRO-α indicate that it may have potential as a candidate biomarker for elderly COPD patients. There was no difference of eosinophils-related chemokines in allergic and non-allergic COPD. These results indicated that both adipokines and eosinophil-related chemokines only play trivial roles in the pathogenesis of COPD.
Authors:
Jaw-Ji Tsai; En-Chih Liao; Jeng-Yuan Hsu; Wen-Jane Lee; Yiu-Kay Lai
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of asthma : official journal of the Association for the Care of Asthma     Volume:  47     ISSN:  1532-4303     ISO Abbreviation:  J Asthma     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-08     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106454     Medline TA:  J Asthma     Country:  England    
Other Details:
Languages:  eng     Pagination:  1040-4     Citation Subset:  IM    
Affiliation:
Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. jawji@vghtc.gov.tw
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MeSH Terms
Descriptor/Qualifier:
Acaridae / immunology
Aged, 80 and over
Animals
Biological Markers / blood
Enzyme-Linked Immunosorbent Assay
Eosinophils / immunology*
Female
Humans
Hypersensitivity / immunology*
Immunoglobulin E / blood
Inflammation / immunology
Inflammation Mediators / blood
Male
Neutrophils / immunology*
Pulmonary Disease, Chronic Obstructive / immunology*
Pyroglyphidae / immunology
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Inflammation Mediators; 37341-29-0/Immunoglobulin E

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