Document Detail


A difference in systolic blood pressure between arms and between lower limbs is a novel risk marker for diabetic nephropathy in patients with Type 2 diabetes.
MedLine Citation:
PMID:  23324865     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent studies have demonstrated that a difference in systolic blood pressure (SBP) between arms is associated with both vascular disease and mortality. The aim of this study was to investigate the relationship between a difference in SBP between arms and between lower limbs and the degree of albuminuria, which is an established marker for cardiovascular disease and diabetic nephropathy in patients with Type 2 diabetes. We measured blood pressure in the arms and lower limbs of 314 consecutive patients with Type 2 diabetes, and we calculated a difference in SBP between arms and between lower limbs. We then evaluated the relationship of the difference in SBP between arms and between lower limbs to the degree of urinary albumin excretion (UAE). The average difference in SBP between arms and between lower limbs was 3.52±3.94 and 9.66±14.1 mm Hg, respectively. Multiple regression analyses demonstrated that a difference in SBP between arms (β=0.172, P=0.0239) and between lower limbs (β=0.238, P=0.0033) independently correlated with the logarithm of the UAE. Multiple logistic regression analyses showed that a difference in SBP of 10 mm Hg between arms (odds ratio 12.23 (95% CI 1.130-132.35), P<0.0393) and a difference in SBP of 15 mm Hg between lower limbs (odds ratio 4.291 (95% CI 1.403-13.123), P<0.0106) correlated with the risk of albuminuria. A difference in SBP between arms and between lower limbs, therefore, could be a novel risk marker for diabetic nephropathy in patients with Type 2 diabetes.Hypertension Research advance online publication, 17 January 2013; doi:10.1038/hr.2012.207.
Authors:
Hiroshi Okada; Michiaki Fukui; Muhei Tanaka; Shinobu Matsumoto; Yusuke Mineoka; Naoko Nakanishi; Mai Asano; Masahiro Yamazaki; Goji Hasegawa; Naoto Nakamura
Related Documents :
6863665 - Computed tomography of the diaphragm: peridiaphragmatic fluid localization.
23585665 - Validation of a novel method for determining the renal threshold for glucose excretion ...
17213625 - Characterization of a glucose sensor prepared by electropolymerization of pyrroles cont...
11742735 - Polypyrrole-hydrogel composites for the construction of clinically important biosensors.
22914565 - Science, clinical outcomes and the popularization of diabetes surgery.
20089385 - Insulin-mimetic action of conglutin-γ, a lupin seed protein, in mouse myoblasts.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-17
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  -     ISSN:  1348-4214     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evaluation of a rapid and simple placental growth factor test in hypertensive disorders of pregnancy...
Next Document:  A cutoff point for arterial stiffness using the cardio-ankle vascular index based on carotid arterio...