Document Detail

The dietary lysine requirement of sows increases in late gestation.
MedLine Citation:
PMID:  23048137     Owner:  NLM     Status:  Publisher    
Current AA recommendations for sows are to provide a fixed amount of AA intake throughout gestation; however, the demand for nutrients changes from maternal lean tissue in early gestation (EG) to fetal and mammary growth in late gestation (LG). The objective of this study was to determine the Lys requirement in EG (d 24 to 45) and LG (d 86 to 110) using the indicator AA oxidation method with simultaneous determination of heat production. Each of 7 Large White x Landrace sows received 6 diets in random order in both EG and LG. Three semi-synthetic diets (14.0 MJ ME/kg) based on corn were formulated and mixed to produce a base diet (60% of the 1998 NRC Lys requirement) and high diets for EG and LG (150 and 185% of the 1998 NRC Lys requirements, respectively). The 6 test diets provided Lys intakes of 7.5 to 19.3 g/d in EG and 8.1 to 23.7 g/d in LG. Sows were placed in respiration chambers and expired air and blood were collected every 30 min for 5.5 h. The tracer AA, L-[1-(13)C]Phe, was given orally at a rate of 2 mg/(kg BWh) over the last 4 h, divided into eight 0.5-h meals. Expired air was measured for (13)CO(2) enrichment and plasma for L-[1-(13)C]Phe enrichment and free Lys concentration. Background (13)CO(2) was subtracted from plateau (13)CO(2) enrichment. Requirements were determined using a 2-phase nonlinear model. Mean maternal gain in gestation (43.7 kg; pooled SE, 1.2 kg), litter size (14.6 total born piglets; pooled SE, 0.8), and litter weight (19.4 kg; pooled SE, 0.9 kg) did not differ between parities. Sow weight gain and BW was greater (P = 0.001) in LG (d 86 to 110) than EG (d 24 to 45). Lysine requirement was 9.4 and 17.4 g/d in EG and LG, respectively. Phenylalanine retention in LG was maximized at a Lys intake of 17.7 g/d. Heat production was greater (P = 0.069) and energy retention lower (P = 0.019) in LG compared to EG. Energy retention in LG was not different from zero. Quantitative Phe kinetics in EG were not affected by Lys intake. In LG, Phe retention increased with Lys intake (P = 0.004), while Phe oxidation decreased (P = 0.005). The Lys requirement was determined to be lower than current recommendations in EG and greater than current recommendations in LG. To meet the change in requirements, diets with increased lysine content are needed in LG. Increasing the feed allowance in LG is necessary to maintain a positive energy balance throughout gestation.
R S Samuel; S Moehn; P B Pencharz; R O Ball
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-9
Journal Detail:
Title:  Journal of animal science     Volume:  -     ISSN:  1525-3163     ISO Abbreviation:  J. Anim. Sci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003002     Medline TA:  J Anim Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta T6G 2P5, Canada.
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