Document Detail

A dietary fibre supplement in the treatment of mild hypertension. A randomized, double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  1313484     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the effects of a dietary fibre supplement given as monotherapy upon blood pressure in mildly hypertensive patients. DESIGN: The investigation was performed as a prospective randomized, double-blind, placebo-controlled trial for 3 months. SETTING: Patients attending an outpatient hypertension clinic in a hospital. PATIENTS: Hypertensive patients with a minimum of two diastolic blood pressure (DBP) readings greater than 90 mmHg during a 2-week run-in period were included. Of the 65 patients enrolled, 63 were randomized (32 fibre, 31 placebo). Six patients did not complete the trial. INTERVENTION: Patients were treated with either fibre (7 g/day) or matching placebo. MAIN OUTCOME MEASURE: Based on previous studies, the a priori hypothesis was that dietary fibre supplementation could reduce blood pressure in hypertensive patients. RESULTS: Body weight was significantly reduced in the fibre group. Dietary fibre significantly reduced DBP and fasting serum insulin. However, no correlation between changes in body weight and systolic blood pressure or DBP was found. CONCLUSION: A dietary fibre supplement can lower DBP in mildly hypertensive patients independent of changes in body weight.
K Eliasson; K R Ryttig; B Hylander; S Rössner
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of hypertension     Volume:  10     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-05-07     Completed Date:  1992-05-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Blood Pressure / physiology
Dietary Fiber / therapeutic use*
Double-Blind Method
Hypertension / blood,  diet therapy*,  epidemiology
Middle Aged
Prospective Studies
Time Factors
Weight Loss

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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