| Is dietary fat associated with the risk of colorectal cancer? A meta-analysis of 13 prospective cohort studies. | |
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MedLine Citation:
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PMID: 20697723 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: The results of animal studies suggest there is a significant role for dietary fat in the development of colorectal cancer (CRC). However, inconsistent results have been reported by epidemiological studies. AIM OF STUDY: To evaluate the association between total dietary fat and risk of colorectal cancer development using a meta-analysis based on prospective cohort studies. METHODS: Published literature was retrieved from Medline, Embase and CNKI (China Knowledge Resource Integrated Database) databases updated to 1st May, 2009. Overall, thirteen prospective cohort studies with 3,635 cases and 459,910 participants were included. RESULTS: The combined relative risk (RR) [95% confidence interval (95%CI)] for the risk of CRC was 0.99 (0.89,1.09) when the highest level of total dietary fat was versus (vs.) the lowest level. Stratified analyses according to gender, ethnicity, country and age showed that the highest level of total dietary fat did not increase the risk of CRC [RR (95%CI): 0.89 (0.77,1.03) for males; 1.09 (0.94,1.26) for females; 1.08 (0.94,1.25) for Caucasians; 0.90 (0.77,1.04) for Asians; 1.13 (0.94,1.36) for Americans; 0.92 (0.81,1.04) for individuals older than 40]. Besides those, the highest level of total fat diet also did not increase the risk of neither colon cancer [RR (95%CI): 0.96 (0.82,1.13)] nor rectal cancer [RR (95%CI):1.07 (0.63,1.82)]. Furthermore, neither animal fat nor plant fat were associated with the risk of CRC [RR (95%CI): 1.05 (0.91-1.22) for animal fat and 0.96 (0.82-1.11) for plant fat]. CONCLUSIONS: This meta-analysis suggests that dietary fat may not be associated with the increased risk of CRC. More well-designed studies with larger population performed among Asians are needed to further evaluate the associations. In addition, probable bias caused by measurement error should be noticed in this meta-analysis, and measurement error needs to be adjusted in the future studies. |
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Authors:
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Liu Liu; Wen Zhuang; Ruo-Qi Wang; Rajarshi Mukherjee; Shuo-Meng Xiao; Zhong Chen; Xiao-Ting Wu; Yong Zhou; Hai-Yan Zhang |
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Publication Detail:
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Type: Journal Article Date: 2010-08-10 |
Journal Detail:
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Title: European journal of nutrition Volume: 50 ISSN: 1436-6215 ISO Abbreviation: Eur J Nutr Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888704 Medline TA: Eur J Nutr Country: Germany |
Other Details:
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Languages: eng Pagination: 173-84 Citation Subset: IM |
Affiliation:
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Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Nan Chang University, 330006, Nanchang City, Jiangxi Province, China, wkjyliu@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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