Document Detail

The dietary approaches to stop hypertension (DASH) clinical trial: implications for lifestyle modifications in the treatment of hypertensive patients.
MedLine Citation:
PMID:  11208239     Owner:  NLM     Status:  MEDLINE    
Lifestyle modifications, such as weight loss, sodium restriction, and limiting alcohol consumption, are important components of the initial treatment of hypertensive patients. The Dietary Approaches to Stop Hypertension (DASH) study investigated the effects of dietary patterns on blood pressure in individuals with diastolic blood pressure between 80-95 mmHg. Two different dietary patterns were tested in this feeding study. A diet enriched in fruits and vegetables and a diet enriched in fruits, vegetables, and low-fat dairy products and low in total and saturated fat (combination diet) were compared with a control diet. Dietary intake was adjusted so that participants did not lose weight, and all study diets had comparable sodium intake (approximately 3 grams/day). All meals were provided for 459 participants for an 11-week period. Those randomized to the combination diet (n = 151) had a significant change in systolic (-5.5 mmHg; p < 0.001) and diastolic blood pressure (-3.0 mmHg; p < 0.001) after subtracting the response to the control diet (n = 154). The fruits-and-vegetables diet (n = 154) produced a significant but lesser decrease in blood pressure (systolic, -2.8 mmHg; p < 0.001 and diastolic, -1.1 mmHg; p = 0.07). Hypertensive individuals and African Americans had particularly favorable responses with blood pressure reductions, which were significantly greater than other subgroups. The combination diet was well-accepted and adherence to the diet was high (>90%) for all participants. The DASH combination diet is an effective lifestyle modification for lowering blood pressure in patients with high-normal or Stage 1 hypertension.
P R Conlin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Cardiology in review     Volume:  7     ISSN:  1061-5377     ISO Abbreviation:  Cardiol Rev     Publication Date:    1999 Sep-Oct
Date Detail:
Created Date:  2001-03-16     Completed Date:  2001-05-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284-8     Citation Subset:  IM    
Endocrinology-Hypertension Division, Brigham and Women's Hospital, 221 Longwood Avenue Boston, MA 02115, USA.
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MeSH Terms
Blood Pressure*
Hypertension / diet therapy*
Life Style
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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