| A diet with a struvite relative supersaturation less than 1 is effective in dissolving struvite stones in vivo. | |
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MedLine Citation:
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PMID: 22005442 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Magnesium ammonium phosphate (struvite) is one of the most common minerals found in feline uroliths. Previous studies have shown the efficacy of acidifying calculolytic diets (inducing urine pH < 6·5), in dissolving struvite stones in cats. Recent work in our laboratory found that wet and dry test diets induce a struvite urinary relative supersaturation (RSS) < 1 and that the urine of healthy cats fed the dry test diet dissolved feline struvite stones in vitro. The objective of the present study was to demonstrate the efficacy of those test diets on naturally occurring struvite urocystoliths in cats. A total of twenty-one cats were used, of which seventeen completed the study. Of the seventeen cats, eight were fed the wet test diet and nine the dry test diet. Uroliths dissolved in a median of 18 (10-55) d. In the remaining four cats, uroliths failed to dissolve and were removed surgically. Quantitative analysis showed that these uroliths contained either calcium oxalate or calcium phosphate. The present study demonstrates that diets that induce a struvite RSS < 1 result in struvite stone dissolution in vivo. |
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Authors:
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Doreen M Houston; Heather E Weese; Michelle D Evason; Vincent Biourge; Ingrid van Hoek |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of nutrition Volume: 106 Suppl 1 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: S90-2 Citation Subset: IM |
Affiliation:
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Medi-Cal Royal Canin, Guelph, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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