| A diet high in saturated fat and sucrose alters glucoregulation and induces aortic fatty streaks in New Zealand White rabbits. | |
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MedLine Citation:
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PMID: 12458659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new and convenient animal model for studying peripheral vascular and coronary artery disease in diabetes was established in this study. Male New Zealand White rabbits weighing approximately 2 kg were divided into 2 groups: a normal control group fed standard laboratory chow and a diabetogenic diet-fed group received a high-fat/high-sucrose diet. The high-fat/high-sucrose diet (contained 10% lard and 37% sucrose) feeding was maintained for 6 months. Plasma total cholesterol, high-density lipoprotein (HDL) cholesterol, triglyceride, superoxide dismutase, nitric oxide, nitric oxide synthase, insulin, and glucose were quantitated at monthly or bimonthly intervals. The aortic fatty streak lesions were quantified following lipid staining with Sudan IV. The aortic samples were observed by electron microscopy. High plasma triglyceride and glucose concentrations were induced. At the end of 6 months, the aortic fatty streak lesions were present in the animals' vascular specimens. As far as we know, this is the first report that demonstrates that New Zealand White rabbits can develop obvious aortic fatty streaks by feeding a high-fat/high-sucrose diet. Our results suggest that New Zealand White rabbits fed a high-fat/high-sucrose diet would provide a convenient model for studying peripheral vascular-and coronary artery disease in diabetes. |
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Authors:
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Weidong Yin; Zhonghua Yuan; Zongbao Wang; Baotang Yang; Yongzong Yang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of experimental diabetes research Volume: 3 ISSN: 1560-4284 ISO Abbreviation: Int. J. Exp. Diabetes Res. Publication Date: 2002 Jul-Sep |
Date Detail:
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Created Date: 2002-12-02 Completed Date: 2003-04-25 Revised Date: 2008-11-20 |
Medline Journal Info:
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Nlm Unique ID: 100962067 Medline TA: Int J Exp Diabetes Res Country: United States |
Other Details:
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Languages: eng Pagination: 179-84 Citation Subset: IM |
Affiliation:
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Institute of Cardiovascular Research, Nanhua University Medical College, Hengyang, Hunan, People's Republic of China. wdy20012001@yahoo.com |
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / pathology Aortic Diseases / blood, etiology*, pathology Arteriosclerosis / blood, etiology*, pathology Body Weight / drug effects Diabetes Mellitus / etiology Diet / adverse effects Dietary Fats / administration & dosage* Glucose / metabolism* Male Rabbits Sucrose / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 50-99-7/Glucose; 57-50-1/Sucrose; 61789-99-9/lard |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
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Journal Information Journal ID (nlm-ta): Int J Exp Diabetes Res ISSN: 1560-4284 Publisher: Hindawi Publishing Corporation |
Article Information Download PDF  Copyright ? 2002 Hindawi Publishing Corporation. open-access: This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Received Day: 4 Month: 3 Year: 2002 Accepted Day: 23 Month: 5 Year: 2002 Print publication date: Year: 2002 Volume: 3 Issue: 3 First Page: 179 Last Page: 184 ID: 2478586 PubMed Id: 12458659 Publisher Item Identifier: S168752140200020X DOI: 10.1080/15604280214274 |
| A Diet High in Saturated Fat and Sucrose Alters Glucoregulation and Induces Aortic Fatty Streaks in New Zealand White Rabbits | |
| Weidong Yin12 |
Address: wdy20012001@yahoo.com |
| Zhonghua Yuan12 | |
| Zongbao Wang1 | |
| Baotang Yang1 | |
| Yongzong Yang1 | |
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1Institute of Cardiovascular ResearchNanhua University Medical CollegeHengyang, Hunan421001China |
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2Department of PathophysiologyCentral South University Xiangya Medical CollegeChangsha, HunanChina |
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