Document Detail


A diet enriched with Korean pine nut oil improves mitochondrial oxidative metabolism in skeletal muscle and brown adipose tissue in diet-induced obesity.
MedLine Citation:
PMID:  23140571     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
In this study, we investigated effects of pine nut oil (PNO) on high-fat diet (HFD)-induced obesity and metabolic dysfunction in skeletal muscle and brown adipose tissue (BAT). Male C57BL/6 mice were fed an HFD with 15% energy from lard and 30% either from soybean oil (SBO-HFD) or PNO (PNO-HFD) for 12 weeks. The PNO-HFD resulted in less weight gain and intramuscular lipid accumulation than the SBO-HFD, and was accompanied by up-regulation of transcripts and proteins related to oxidative metabolism and phosphorylation of AMPK, as well as molecules selectively expressed in type I and type IIa muscle fibers. In addition, uncoupling protein-1 was upregulated in BAT. These beneficial metabolic effects were partly associated with the dual ligand activity of pinolenic acid, which is abundant in PNO, for peroxisome proliferator-activated receptors alpha and delta. Our findings suggest that PNO may have potential as a dietary supplement for counteracting obesity and metabolic dysregulation.
Authors:
Ngoc Hoan Le; Sunhye Shin; Thai Hien Tu; Chu Sook Kim; Ji-Hye Kang; Tsuyoshi Goto; Kawada Teruo; Sung Nim Han; Rina Yu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-11
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  -     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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