| The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs. | |
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MedLine Citation:
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PMID: 17497222 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs, such as proton pump inhibitors (PPI) and histamine-2 receptor blocker (H2RB), was compared. Seventy-four consecutive patients on acid-reducing drugs were enrolled: 34 (46%) were on PPIs, 20 (27%) were on H2RBs and 20 (27%) were not on medications. For those patients on PPIs, RUT and histology results from antrum were negative in 28 (82%) and 17 (50%) patients, respectively (OR: 4.7; 95% CI: 1.4-16.6; P = 0.004), while those from the corpus were negative in was 28 (82%) and 18 (53%) patients, respectively (OR: 4.4, 95% CI: 1.3-15.5; P = 0.006). For patients on H2RBs, RUT and histology results from the antrum were negative in 12 (60%) and six (30%) patients, respectively (OR: 3.5; 95% CI: 0.8-16.1; P = 0.05), while those from the corpus were negative in 12 (60%) and nine (45%) patients, respectively (OR: 1.8; 95% CI: 0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT and histology was reduced from both the antrum and corpus. In these patients, PCR for H. pylori is more sensitive than RUT and histology. |
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Authors:
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Javed Yakoob; Wasim Jafri; Zaigham Abbas; Shahab Abid; Muhammad Islam; Zubair Ahmed |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-12 |
Journal Detail:
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Title: Digestive diseases and sciences Volume: 53 ISSN: 0163-2116 ISO Abbreviation: Dig. Dis. Sci. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-17 Completed Date: 2008-02-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7902782 Medline TA: Dig Dis Sci Country: United States |
Other Details:
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Languages: eng Pagination: 95-100 Citation Subset: AIM; IM |
Affiliation:
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Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Antibodies, Bacterial / analysis Biopsy Diagnosis, Differential Female Follow-Up Studies Gastric Mucosa / microbiology, pathology* Gastritis / complications, diagnosis*, drug therapy Gastroscopy / methods* Helicobacter Infections / complications, diagnosis*, microbiology Helicobacter pylori / genetics, immunology, isolation & purification Histamine H2 Antagonists / therapeutic use* Humans Male Middle Aged Polymerase Chain Reaction Proton Pump Inhibitors / therapeutic use* RNA, Bacterial / analysis Retrospective Studies Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Bacterial; 0/Histamine H2 Antagonists; 0/Proton Pump Inhibitors; 0/RNA, Bacterial |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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