Document Detail


The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs.
MedLine Citation:
PMID:  17497222     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The diagnostic yield of various tests for Helicobacter pylori infection in patients on acid-reducing drugs, such as proton pump inhibitors (PPI) and histamine-2 receptor blocker (H2RB), was compared. Seventy-four consecutive patients on acid-reducing drugs were enrolled: 34 (46%) were on PPIs, 20 (27%) were on H2RBs and 20 (27%) were not on medications. For those patients on PPIs, RUT and histology results from antrum were negative in 28 (82%) and 17 (50%) patients, respectively (OR: 4.7; 95% CI: 1.4-16.6; P = 0.004), while those from the corpus were negative in was 28 (82%) and 18 (53%) patients, respectively (OR: 4.4, 95% CI: 1.3-15.5; P = 0.006). For patients on H2RBs, RUT and histology results from the antrum were negative in 12 (60%) and six (30%) patients, respectively (OR: 3.5; 95% CI: 0.8-16.1; P = 0.05), while those from the corpus were negative in 12 (60%) and nine (45%) patients, respectively (OR: 1.8; 95% CI: 0.4-7.8; P = 0.342). For those patients on PPIs, the diagnostic yield of both RUT and histology was reduced from both the antrum and corpus. In these patients, PCR for H. pylori is more sensitive than RUT and histology.
Authors:
Javed Yakoob; Wasim Jafri; Zaigham Abbas; Shahab Abid; Muhammad Islam; Zubair Ahmed
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-12
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-02-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-100     Citation Subset:  AIM; IM    
Affiliation:
Department of Gastroenterology and Pathology, Aga Khan University Hospital, Karachi, Pakistan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Bacterial / analysis
Biopsy
Diagnosis, Differential
Female
Follow-Up Studies
Gastric Mucosa / microbiology,  pathology*
Gastritis / complications,  diagnosis*,  drug therapy
Gastroscopy / methods*
Helicobacter Infections / complications,  diagnosis*,  microbiology
Helicobacter pylori / genetics,  immunology,  isolation & purification
Histamine H2 Antagonists / therapeutic use*
Humans
Male
Middle Aged
Polymerase Chain Reaction
Proton Pump Inhibitors / therapeutic use*
RNA, Bacterial / analysis
Retrospective Studies
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Histamine H2 Antagonists; 0/Proton Pump Inhibitors; 0/RNA, Bacterial

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