Document Detail

The diagnostic value of small bowel wall vascularity after sulfur hexafluoride-filled microbubble injection in patients with Crohn's disease. Correlation with the therapeutic effectiveness of specific anti-inflammatory treatment.
MedLine Citation:
PMID:  19070446     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To assess the value of small bowel wall vascularity after microbubble contrast agent injection in evaluating the therapeutic effectiveness of specific anti-inflammatory treatment in patients with Crohn's disease. MATERIALS AND METHODS: Fifteen patients (7 male and 8 female; mean age+/-SD, 40 years+/-6) with a biopsy-proven diagnosis of Crohn's disease--Crohn's disease activity index (CDAI)>150 (n=12 patients) or <150 (n=3)--involving the terminal loop of the small bowel (wall thickness>5 mm) were included. In each patient the terminal loop was scanned by contrast-enhanced ultrasound (CEUS) after sulfur hexafluoride-filled microbubble injection before and after 6-month anti-inflammatory treatment. The vascularity of the terminal loop was quantified in gray-scale levels (0-255) by a manually drawn ROI encompassing the thickened bowel wall and it was correlated with CDAI. RESULT: Before the beginning of the specific treatment all patients revealed diffuse transparietal contrast enhancement after microbubble injection, except for 3 patients who revealed contrast enhancement limited to the submucosa. In 13 patients the slope of the first ascending tract and the area under the enhancement curve were significantly lower after anti-inflammatory treatment (P<0.05; Wilcoxon test) with a significant correlation with the CDAI score (rho=0.85, P<0.05). In 2 patients no significant vascularity changes were found even though a mild reduction of CDAI score was identified (from 200 to 150 gray-scale levels). CONCLUSION: CEUS is a useful method to assess the therapeutic effectiveness of specific medical anti-inflammatory treatment in patients with Crohn's disease.
Emilio Quaia; Vincenzo Migaleddu; Elisa Baratella; Riccardo Pizzolato; Alexia Rossi; Maurizio Grotto; Maria Assunta Cova
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2008-12-12
Journal Detail:
Title:  European journal of radiology     Volume:  69     ISSN:  1872-7727     ISO Abbreviation:  Eur J Radiol     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-03-30     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8106411     Medline TA:  Eur J Radiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  438-44     Citation Subset:  IM    
Department of Radiology, Cattinara Hospital, University of Trieste, Strada di Fiume 447, 34149 Trieste, Italy.
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MeSH Terms
Anti-Inflammatory Agents / administration & dosage*
Contrast Media
Crohn Disease / drug therapy*,  ultrasonography*
Image Enhancement / methods
Injections, Intravenous
Intestine, Small / blood supply*,  ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Sulfur Hexafluoride / administration & dosage,  diagnostic use*
Treatment Outcome
Ultrasonography / methods*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Contrast Media; 2551-62-4/Sulfur Hexafluoride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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