| The diagnostic value of PET/CT scanning in patients with cervical cancer: a prospective study. | |
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MedLine Citation:
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PMID: 17482666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate the clinical value of PET/CT as a supplement to FIGO staging in patients with cervical cancer stage >or=1B. METHODS: This prospective study included 120 consecutive patients. After staging, a whole-body PET/CT scan was performed and these examinations were divided into two groups: (1) patients suitable for radical hysterectomy including lymph node dissection and (2) patients referred to combined chemo/radiation therapy. The results were compared to histopathological findings and/ or follow-up. RESULTS: Twenty-seven patients underwent radical surgery; four of these had PET/CT scans revealing pathological foci in the pelvis. Three (11%) were true positive; one was false positive. Twenty-two patients had true negative PET/CT scans concerning pelvic lymph nodes. One patient had a false negative node. For these patients, we found the positive predictive value (PPV) to be 75%, negative predictive value (NPV) 96%, sensitivity 75%, specificity 96%. Regarding para-aortal nodal disease in the total population of 119 patients, 15 patients had true positive scans. The number of true negatives was 103, resulting in PPV 94%, NPV 100%, sensitivity 100% and specificity 99%. PET/CT scans showed distant metastases in 19 patients, 10 were true positive and nine were false positive. The remaining 100 patients were considered true negative for distant metastases and for these patients, we found PPV 63%, NPV 100%, sensitivity 100% and specificity 94%. CONCLUSIONS: Whole-body FDG PET/CT scanning for newly diagnosed cervical cancer FIGO stage >or=1B has a high sensitivity and specificity, and can be a valuable supplement to the FIGO staging procedure. |
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Authors:
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Annika Loft; Anne Kiil Berthelsen; Henrik Roed; Christian Ottosen; Lene Lundvall; Jens Knudsen; Lotte Nedergaard; Liselotte Højgaard; Svend Aage Engelholm |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-05-07 |
Journal Detail:
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Title: Gynecologic oncology Volume: 106 ISSN: 0090-8258 ISO Abbreviation: Gynecol. Oncol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-18 Completed Date: 2007-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0365304 Medline TA: Gynecol Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 29-34 Citation Subset: IM |
Affiliation:
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PET and Cyclotron Unit 3982, Department of Clinical Physiology and Nuclear Medicine, Centre of Diagnostic Investigations, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. annika.loft@rh.hosp.dk <annika.loft@rh.hosp.dk> |
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| MeSH Terms | |
Descriptor/Qualifier:
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Bone Neoplasms
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radionuclide imaging,
secondary Female Fluorodeoxyglucose F18 / diagnostic use Humans Lymph Nodes / pathology, radionuclide imaging Lymphatic Metastasis Neoplasm Staging Positron-Emission Tomography / methods Prospective Studies Radiopharmaceuticals / diagnostic use Tomography, X-Ray Computed / methods Uterine Cervical Neoplasms / pathology*, radionuclide imaging*, surgery |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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