| The diagnostic value of positron emission tomography (PET) with radiolabelled fluorodeoxyglucose (18F-FDG) in head and neck cancer. | |
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MedLine Citation:
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PMID: 10605586 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Positron emission tomography (PET) scanning has recently been introduced into clinical practice but its usefulness in the management of head and neck cancer is not well defined. The aim of this prospective preliminary study was to examine the clinical value of fluorodeoxyglucose (FDG)--PET in patients with head and neck cancer treated by radiotherapy with surgery in reserve by (i) relating quantitative uptake of isotope to tumour type and histological grade and (ii) comparing the imaging findings of PET and magnetic resonance imaging (MRI) in post-radiotherapy assessment of tumour response. Twenty-one patients had pre-treatment PET and MRI scans and these were repeated four and eight months after treatment if there was no clinical relapse. Pre-treatment uptake of FDG using tumour to cerebellar ratio parameters was significantly related to the histological grade of squamous cancer (p = 0.04) but not to tumour type. Discordance of post-treatment PET/MRI findings in one case indicates a possible role for PET in the early detection of tumour recurrence. Other potential uses of PET scanning in the management of head and neck cancer are discussed. |
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Authors:
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N J Slevin; C D Collins; D L Hastings; M L Waller; R J Johnson; R A Cowan; A R Birzgalis; W T Farrington; R Swindell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of laryngology and otology Volume: 113 ISSN: 0022-2151 ISO Abbreviation: J Laryngol Otol Publication Date: 1999 Jun |
Date Detail:
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Created Date: 2000-01-10 Completed Date: 2000-01-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8706896 Medline TA: J Laryngol Otol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 548-54 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Oncology, Christie Hospital NHS Trust, Manchester, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carcinoma, Squamous Cell / radionuclide imaging*, radiotherapy Female Fluorodeoxyglucose F18 / diagnostic use* Head and Neck Neoplasms / radionuclide imaging*, radiotherapy Humans Laryngeal Neoplasms / radionuclide imaging, radiotherapy Magnetic Resonance Imaging Male Middle Aged Nose Neoplasms / radionuclide imaging, radiotherapy Pilot Projects Predictive Value of Tests Prospective Studies Radiopharmaceuticals / diagnostic use* Tomography, Emission-Computed* Tonsillar Neoplasms / radionuclide imaging, radiotherapy |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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