Document Detail


The diagnostic value of beta-human chorionic gonadotropin, progesterone, CA125 in the prediction of abortions.
MedLine Citation:
PMID:  20373934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was conducted to investigate the effectiveness of serum levels of free beta-hCG, progesterone, CA125 and their combined use in the prediction of first trimester abortions. A total of 140 singleton pregnant women between 5 and 13 weeks' gestational age were included as Group I (n = 21) who resulted in abortion including missed abortion, incomplete abortion, complete abortion and inevitable abortion; Group II (n = 129) included normal pregnancies. When using the free beta-hCG level of <20 ng/ml as a cut off point, the sensitivity, specificity, PPV and NPV were 91%, 82%, 46% and 98%, when using a progesterone of <15 ng/ml as a cut off point, they were 91%, 89%, 59%, 98%. The single measurement of free beta-hCG or progesterone levels can be useful in the prediction of first trimester spontaneous abortions, but using progesterone may be recommended since it has high availability and low cost.
Authors:
M A Osmanağaoğlu; I Erdoğan; S Eminağaoğlu; S C Karahan; S Ozgün; G Can; H Bozkaya
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  30     ISSN:  1364-6893     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-08     Completed Date:  2010-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  288-93     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Karadeniz Technical University, Trabzon, Turkey. drmaosmanaga@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / diagnosis*
Adult
CA-125 Antigen / blood*
Chorionic Gonadotropin, beta Subunit, Human / blood*
Female
Humans
Immunoassay / economics,  methods
Logistic Models
Membrane Proteins / blood*
Predictive Value of Tests
Pregnancy
Pregnancy Trimester, First
Progesterone / blood*
Prospective Studies
Turkey
Young Adult
Chemical
Reg. No./Substance:
0/CA-125 Antigen; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/MUC16 protein, human; 0/Membrane Proteins; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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