| The diagnostic significance of serum creatine kinase-BB isoenzyme in adenocarcinoma of prostate. | |
| | |
MedLine Citation:
|
PMID: 7418193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The relative diagnostic usefulness of total serum acid phosphatase, tartrate-inhibited fraction of acid phosphatase, immunoreactive prostatic acid phosphatase, and creatine kinase-BB isoenzyme was evaluated in 30 patients with biopsy-proven adenocarcinoma of prostate. The total and tartrate-inhibited acid phosphatase, measured by standard chemical methods, were elevated in 8 patients with stage D disease. The radioimmunoassay (RIA) method confirmed these abnormal values and also indicated the presence of elevated prostatic serum acid phosphatase in 3 additional patients. The electrophoretic fractionation of total serum creatine kinase (CK) into its various isoenzyme components showed the presence of CK-BB isoenzyme in 8 patients. In 5 of these patients with detectable CK-BB isoenzyme, RIA values for prostatic acid phosphatase were also elevated. Histologic studies of the prostatic tissues revealed that the presence of serum CK-BB was invariably associated with poorly differentiated adenocarcinoma of prostate. The results of the present studies indicate that 1) with simultaneous measurements of serum CK-BB and immunoreactive prostatic acid phosphatase laboratory confirmation of prostatic cancer can be obtained in 50 per cent of patients; 2) determination of total and tartrate-inhibited acid phosphatase along with CK-BB and immunoreactive prostatic acid phosphatase does not increase the frequency of correct diagnosis; and 3) the presence of serum CL-BB isoenzyme is suggestive of poorly differentiated adenocarcinoma of prostate. |
| | |
Authors:
|
H Aleyassine; S G MacIsaac |
Related Documents
:
|
8175913 - Okadaic acid induces dephosphorylation of histone h1 in metaphase-arrested hela cells. 3129433 - Pho5-lacz hybrid proteins block translocation of native acid phosphatase in saccharomyc... 16941233 - Potential gamma-hydroxybutyric acid (ghb) drug interactions through blood-brain barrier... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical biochemistry Volume: 13 ISSN: 0009-9120 ISO Abbreviation: Clin. Biochem. Publication Date: 1980 Jun |
Date Detail:
|
Created Date: 1980-12-18 Completed Date: 1980-12-18 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: CANADA |
Other Details:
|
Languages: eng Pagination: 109-12 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acid Phosphatase
/
blood Adenocarcinoma / blood, diagnosis* Clinical Enzyme Tests Creatine Kinase / blood* Humans Isoenzymes Male Prostatic Neoplasms / blood, diagnosis* |
| Chemical | |
Reg. No./Substance:
|
0/Isoenzymes; EC 2.7.3.2/Creatine Kinase; EC 3.1.3.2/Acid Phosphatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Diet and medications giving positive ninhydrin reactions on TLC in a newborn urinary screening progr...
Next Document: Arylesterase isoenzymes and activity in normal healthy adults and in patients with cancer and with o...