| The diagnostic significance of the immunoglobulin A to M and A to total ratios in the pancreatoduodenal fluid of patients with benign and malignant pancreatic diseases. | |
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MedLine Citation:
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PMID: 356594 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunoglobulins A, M and G in the pancreato-duodenal fluid (PDF) of 35 pancreatic disease-free individuals and 48 patients with chronic pancreatitis (25), hypersecretory disorders (10), renal transplanted (4) and with pancreatic cancer (9), were determined by a single radial immunodiffusion method. Although a trend of immunoglobulin hypersecretion in benign diseases and hyposecretion in malignancies was present, individual levels of Ig-A and Ig-M differed statistically only between cancer and other groups. Calculating the ratios of Ig-A to Ig-M (A/M) and Ig-A to total immunoglobulin contents (A/T) in the PDF of patients with chronic pancreatitis or cancer, however, a significantly higher or lower ratio, respectively, was found compared to control group. Differences in A/M ratios could not be detected between patients with benign diseases, but were constantly present when these patients were compared to pancreatic cancer. The underlying mechanism(s) of the disturbed immunosecretory system in pancreatic diseases remains speculative. Nevertheless, immunoglobulin measurements in the PDF of patients with pancreatic diseases offer a simple diagnostic aid in clinical differentiation of pancreatic pathology. |
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Authors:
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J P Bramis; J Messer; M Nacchiero; D A Dreiling |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of gastroenterology Volume: 69 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 1978 May |
Date Detail:
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Created Date: 1978-10-18 Completed Date: 1978-10-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 565-71 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Body Fluids
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immunology* Duodenum / immunology*, secretion Humans Immunoglobulin A / analysis* Immunoglobulin M / analysis* Kidney Transplantation Pancreas / immunology*, secretion Pancreatic Diseases / immunology* Pancreatic Neoplasms / immunology Pancreatitis / immunology Transplantation, Homologous |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A; 0/Immunoglobulin M |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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