Document Detail

The diagnostic significance of immunoglobulin and fibrin deposition in lichen planus.
MedLine Citation:
PMID:  1191524     Owner:  NLM     Status:  MEDLINE    
Direct immunofluorescent (IF) staining was performed on biopsy specimens from fifty-three patients with active lichen planus. In fifteen of these cases uninvolved skin sites were also examined. Globular or cytoid body-like deposits of immunoglobulins, mainly IgM, were detected in forty-six of the active lesions, and in half the uninvolved skin biopsies. The deposition of fibrin in the papillary dermis and around follicular structures was seen only in the active lichen planus papules. The significance of these findings was assessed by comparison with the IF results obtained in 252 biopsies from various cutaneous disorders, stained by the same technique during the period of this study. Although the presence of immunoglobulin cytoid bodies and fibrin was found to be highly characteristic of lichen planus, these findings were not specifically diagnostic. Morphologically identical deposits were seen not infrequently in lupus erythematosus and in eczema. Active lesions of dermatitis herpetiformis, erythema multiforme and other rare dermatoses also showed these cytoid body-like immunoglobulin deposits.
E Abell; D G Presbury; R Marks; D Ramnarain
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of dermatology     Volume:  93     ISSN:  0007-0963     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  1975 Jul 
Date Detail:
Created Date:  1976-02-13     Completed Date:  1976-02-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-24     Citation Subset:  IM    
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MeSH Terms
Fibrin* / analysis
Immunoglobulin M / analysis
Immunoglobulins* / analysis
Lichen Planus / diagnosis*,  immunology
Lupus Erythematosus, Systemic / diagnosis,  immunology
Skin / immunology*
Reg. No./Substance:
0/Immunoglobulin M; 0/Immunoglobulins; 9001-31-4/Fibrin

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