Document Detail

A diagnostic cycle test for McArdle's disease.
MedLine Citation:
PMID:  14520671     Owner:  NLM     Status:  MEDLINE    
We investigated whether the second wind phenomenon (ie, a decrease in heart rate and perceived exertion during exercise) is pathognomonic for McArdle's disease. Twenty-four patients with McArdle's disease, 17 healthy subjects, and 25 patients with other inborn errors of muscle metabolism cycled a constant workload for 15 minutes. In McArdle's disease patients, heart rate consistently decreased by 35 +/- 3 beats per minute from the 7(th) to the 15(th) minute of exercise, whereas heart rate increased progressively with exercise in all 42 control subjects. The findings indicate that cycling at a moderate, constant workload provides a specific, sensitive, and simple diagnostic test for McArdle's disease.
John Vissing; Ronald G Haller
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of neurology     Volume:  54     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-01     Completed Date:  2003-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-42     Citation Subset:  IM    
Department of Neurology and Copenhagen Muscle Research Center, National University Hospital, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Case-Control Studies
Exercise / physiology
Exercise Test*
Exercise Therapy
Glycogen Storage Disease Type V / diagnosis*,  physiopathology
Heart Rate / physiology
Metabolism, Inborn Errors / diagnosis*,  physiopathology*
Predictive Value of Tests
Reproducibility of Results
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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