Document Detail

A diagnostic approach in Alzheimer's disease using three-dimensional stereotactic surface projections of fluorine-18-FDG PET.
MedLine Citation:
PMID:  7790950     Owner:  NLM     Status:  MEDLINE    
To improve the diagnostic performance of PET as an aid in evaluating patients suspected of having Alzheimer's disease, we developed a fully automated method which generates comprehensive image presentations and objective diagnostic indices. METHODS: Fluorine-18-fluorodeoxyglucose PET image sets were collected from 37 patients with probable Alzheimer's disease (including questionable and mild dementia), 22 normal subjects and 5 patients with cerebrovascular disease. Following stereotactic anatomic standardization, metabolic activity on an individual's PET image set was extracted to a set of predefined surface pixels (three-dimensional stereotactic surface projection, 3D-SSP), which was used in the subsequent analysis. A normal database was created by averaging extracted datasets of the normal subjects. Patients' datasets were compared individually with the normal database by calculating a Z-score on a pixel-by-pixel basis and were displayed in 3D-SSP views for visual inspections. Diagnostic indices were then generated based on averaged Z-scores for the association cortices. RESULTS: Patterns and severities of metabolic reduction in patients with probable Alzheimer's disease were seen in the standard 3D-SSP views of extracted raw data and statistical Z-scores. When discriminating patients with probable Alzheimer's disease from normal subjects, diagnostic indices of the parietal association cortex and unilaterally averaged parietal-temporal-frontal cortex showed sensitivities of 95% and 97%, respectively, with a specificity of 100%. Neither index yielded false-positive results for cerebrovascular disease. CONCLUSION: 3D-SSP enables quantitative data extraction and reliable localization of metabolic abnormalities by means of stereotactic coordinates. The proposed method is a promising approach for interpreting functional brain PET scans.
S Minoshima; K A Frey; R A Koeppe; N L Foster; D E Kuhl
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of nuclear medicine : official publication, Society of Nuclear Medicine     Volume:  36     ISSN:  0161-5505     ISO Abbreviation:  J. Nucl. Med.     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-07-27     Completed Date:  1995-07-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0217410     Medline TA:  J Nucl Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1238-48     Citation Subset:  IM    
Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
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MeSH Terms
Alzheimer Disease / metabolism,  radionuclide imaging*
Brain / metabolism,  radionuclide imaging*
Deoxyglucose / analogs & derivatives*,  diagnostic use
Fluorine Radioisotopes / diagnostic use*
Fluorodeoxyglucose F18
Glucose / metabolism
Middle Aged
Sensitivity and Specificity
Stereotaxic Techniques*
Tomography, Emission-Computed*
Grant Support
Reg. No./Substance:
0/Fluorine Radioisotopes; 154-17-6/Deoxyglucose; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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