Document Detail


The diagnostic accuracy of carbohydrate-deficient transferrin, sialic acid and commonly used markers of alcohol abuse during abstinence.
MedLine Citation:
PMID:  16087169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The normalization of alcohol abuse markers during the abstinence depends on the time since the last drinking. The aim of this study was to evaluate the diagnostic accuracy (area under the curve-AUC, sensitivity and specificity) of CDT, sialic acid and others biochemical and hematological markers of chronic alcohol abuse during abstinence. METHODS: We studied 75 patients admitted to the treatment of alcohol dependence. The blood samples were collected upon admission to the hospital. CDT was estimated using an immunoturbidimetric assay after anion-exchange chromatography and sialic acid by enzymatic colorimetric method. RESULTS: Mean values of all markers were significantly higher. All tests, except SA, negatively correlated with time of abstinence but not with age, duration of dependence and amounts of weekly alcohol consumption. The area under the curve (AUC) for all tested markers decreased progressively during the abstinence. The highest AUC was obtained for CDT (0.98) and the lowest for ALT (0.78) when alcohol was consumed in the last week. AUC for sialic acid was lower than of CDT but higher than of ALT. CONCLUSIONS: We conclude that the diagnostic accuracy for tested laboratory markers depends on the self-reported time of abstinence being the highest for CDT in the first week of abstinence. The accuracy of sialic acid was observed between GGT and ALT.
Authors:
Lech Chrostek; Bogdan Cylwik; Maciej Szmitkowski; Walenty Korcz
Related Documents :
318339 - Isolation and chemical composition of the leucocytes from donkey, horse, mule and pig.
6506059 - Acidic glycopeptides isolated from young human aortas.
14760639 - Capillary zone electrophoresis for determination of carbohydrate-deficient transferrin ...
17603199 - Determination of the absolute configuration of sialic acids in gangliosides from the se...
3102059 - Analysis of the chain length of oligomers and polymers of sialic acid isolated from nei...
5696869 - The isolation and characterization of a glycoprotein from human thoracic aorta.
2858469 - Involvement of autolysin in cellular lysis of bacillus subtilis induced by short- and m...
5903109 - Comparison of two serologically distinct ribonucleic acid bacteriophages. i. properties...
21339119 - Quality changes during storage of minced fish products containing dietary fiber and for...
Publication Detail:
Type:  Journal Article     Date:  2005-08-08
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  364     ISSN:  0009-8981     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-23     Completed Date:  2006-04-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  167-71     Citation Subset:  IM    
Affiliation:
Department of Biochemical Diagnostics, Medical University, Washington Street 15A, 15-269 Bialystok, Poland. chrostek@amb.edu.pl
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alanine Transaminase / blood
Alcoholism / blood*,  diagnosis
Aspartate Aminotransferases / blood
Biological Markers / blood*
Erythrocyte Indices
Humans
Male
Middle Aged
N-Acetylneuraminic Acid / blood*
Sensitivity and Specificity
Temperance*
Transferrin / analogs & derivatives*,  analysis
gamma-Glutamyltransferase / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/carbohydrate-deficient transferrin; 11096-37-0/Transferrin; 131-48-6/N-Acetylneuraminic Acid; EC 2.3.2.2/gamma-Glutamyltransferase; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Plasma free amino acids and their metabolites in Taiwanese patients on hemodialysis and continuous a...
Next Document:  Competence and performance in belief-desire reasoning across two cultures: the truth, the whole trut...