Document Detail


The diagnosis and treatment of Mullerian adenosarcoma of the uterus.
MedLine Citation:
PMID:  19133051     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Adenosarcoma of the uterus is one of the rare types of gynaecological malignant tumours. Poor awareness of it among clinicians makes it difficult to diagnose correctly and timely, so it is helpful to enrich and update our knowledge about the tumour with new information of patients. AIM: To improve the level of diagnosis and treatment of Mullerian adenosarcoma of the uterus. METHODS: The medical data of nine patients with Mullerian adenosarcoma of the uterus who were treated from May 1995 to March 2006 in our hospital were analysed retrospectively. The analysis focused on clinicopathological features, treatment and prognosis. RESULTS: Patients typically presented with abnormal uterine bleeding, pain in the lower abdomen, enlargement of the uterus, a mass in the uterine cavity and/or a cervical neoplasm. Microscopically, the glands were lined by benign or atypical glandular epithelium, together with sarcomatous stromal cells which showed characteristic structures of 'periglandular cuff' of increased cellularity and 'intraglandular polypoid projections'. The primary diagnostic rate was 33.3% and the average interval from symptom onset to final diagnosis was 13 months and eight weeks for pre- and postmenopausal patients, respectively. The prognosis was better in early stage disease in young patients. CONCLUSIONS: The most common symptom of adenosarcoma of the uterus is abnormal uterine bleeding. Younger patients are more often misdiagnosed. Clinical stage and age of the patient are closely related to prognosis. Surgery is the primary treatment, and chemotherapy may be somewhat beneficial.
Authors:
Yangyang Shi; Zhiqiang Liu; Zhilan Peng; Hui Liu; Kaixuan Yang; Xianying Yao
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Australian & New Zealand journal of obstetrics & gynaecology     Volume:  48     ISSN:  1479-828X     ISO Abbreviation:  Aust N Z J Obstet Gynaecol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-09     Completed Date:  2009-04-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0001027     Medline TA:  Aust N Z J Obstet Gynaecol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  596-600     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, China. shining79521@126.com
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MeSH Terms
Descriptor/Qualifier:
Adenosarcoma / diagnosis*,  drug therapy,  surgery
Adult
Age Factors
Diagnosis, Differential
Female
Humans
Middle Aged
Mixed Tumor, Mullerian / diagnosis*,  drug therapy,  surgery
Neoplasm Staging
Neoplasms, Germ Cell and Embryonal / diagnosis*,  drug therapy,  surgery
Prognosis
Retrospective Studies
Treatment Outcome
Uterine Cervical Neoplasms / diagnosis*,  drug therapy,  surgery
Uterine Neoplasms / diagnosis*,  drug therapy,  surgery
Young Adult

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