Document Detail


The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate.
MedLine Citation:
PMID:  19026340     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intraventricular hemorrhage (IVH) occurs in 20% to 25% of very low birthweight preterm neonates and may be associated with significant sequelae. Infants who have IVH are at risk for posthemorrhagic hydrocephalus and periventricular leukomalacia; as many as 75% of those who have parenchymal involvement of hemorrhage suffer significant neurodevelopmental disability. Because of the prevalence of IVH and the medical and societal impact of this disease, many postnatal pharmacologic prevention strategies have been explored. Randomized clinical prevention trials should provide long-term neurodevelopmental follow-up to assess the impact of preterm birth, injury, and pharmacologic intervention on the developing brain.
Authors:
Heather J McCrea; Laura R Ment
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Clinics in perinatology     Volume:  35     ISSN:  1557-9840     ISO Abbreviation:  Clin Perinatol     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-03-10     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  7501306     Medline TA:  Clin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-92, vii     Citation Subset:  IM    
Affiliation:
Yale University School of Medicine, New Haven, CT 06510, USA.
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MeSH Terms
Descriptor/Qualifier:
Cerebral Hemorrhage / complications,  diagnosis*,  physiopathology,  prevention & control*
Cerebral Ventricles / blood supply*
Coagulants / therapeutic use
Cyclooxygenase Inhibitors / therapeutic use
Factor VIIa / therapeutic use
Humans
Ibuprofen / therapeutic use
Indomethacin / therapeutic use
Infant, Newborn
Infant, Premature*
Phenobarbital / therapeutic use
Grant Support
ID/Acronym/Agency:
NS 27116/NS/NINDS NIH HHS; NS 53865/NS/NINDS NIH HHS; R01 NS027116-19/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Coagulants; 0/Cyclooxygenase Inhibitors; 15687-27-1/Ibuprofen; 50-06-6/Phenobarbital; 53-86-1/Indomethacin; EC 3.4.21.21/Factor VIIa
Comments/Corrections

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