Document Detail

The diagnosis and management of Kawasaki disease.
MedLine Citation:
PMID:  15790316     Owner:  NLM     Status:  MEDLINE    
Kawasaki disease (KD) is a systemic vasculitis of childhood with a predilection for the coronary arteries. It is the predominant cause of paediatric acquired heart disease in developed countries. The aetiology of KD remains unknown and consequently there is no diagnostic test. The diagnosis is made using a constellation of clinical criteria that in isolation have poor sensitivity and specificity. Early treatment prevents overt coronary artery damage in the majority of children. The long-term effects of childhood KD on later cardiovascular health remain unknown. A recent study showed that treatment of KD in Australia is suboptimal, with late diagnosis occurring in approximately half of the cases and an unacceptably high incidence of acute cardiac involvement. These guidelines highlight the difficulties in the diagnosis of KD and offer some clues that may assist early recognition of this important paediatric disease. They also detail current treatment recommendations and the evidence on which they are based. Increased awareness of the epidemiology and spectrum of the clinical presentation of KD is essential for early recognition and optimal management.
J Royle; D Burgner; N Curtis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of paediatrics and child health     Volume:  41     ISSN:  1034-4810     ISO Abbreviation:  J Paediatr Child Health     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-25     Completed Date:  2005-07-07     Revised Date:  2007-09-24    
Medline Journal Info:
Nlm Unique ID:  9005421     Medline TA:  J Paediatr Child Health     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  IM    
Department of General Medicine, Royal Children's Hospital, Melbourne, Victoria, Australia.
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MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
Aspirin / therapeutic use*
Child, Preschool
Immunoglobulins, Intravenous*
Mucocutaneous Lymph Node Syndrome* / diagnosis,  drug therapy,  physiopathology
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Immunoglobulins, Intravenous; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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