| The diagnosis of idiopathic thrombocytopenic purpura in adults: does bone marrow biopsy have a place? | |
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MedLine Citation:
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PMID: 10092918 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To assess the value of routine bone marrow biopsy (BMB) in adult patients less than 65 years of age with suspected idiopathic thrombocytopenic purpura (ITP). DESIGN: Retrospective analysis. Data were collected from hospital medical records and laboratory results. SETTING: Large tertiary-level metropolitan teaching hospital, Victoria. PARTICIPANTS: Sixty-six patients who had undergone BMB for investigation of isolated thrombocytopenia between January 1992 and May 1997, according to defined eligibility criteria. RESULTS: Sixty-one of the 66 patients had BMB findings consistent with ITP (i.e., normal or increased numbers of megakaryocytes and other haemopoietic lineages normal). Three of these patients' biopsies incidentally showed reduced or absent iron stores. In the remaining five patients, BMB in four showed mild hypocellularity and the subsequent course in these patients was consistent with chronic ITP. The fifth patient had neutrophil hypersegmentation and giant band cells on BMB, the cause of which was unclear. The subsequent course in this patient has also been consistent with chronic ITP. CONCLUSIONS: Our data suggest that the routine performance of BMB for the diagnosis of ITP is not useful, provided that a thorough clinical history and physical examination are undertaken and that the blood count and peripheral blood smear show no abnormalities apart from thrombocytopenia. |
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Authors:
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D A Westerman; A P Grigg |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Medical journal of Australia Volume: 170 ISSN: 0025-729X ISO Abbreviation: Med. J. Aust. Publication Date: 1999 Mar |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0400714 Medline TA: Med J Aust Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 216-7 Citation Subset: IM |
Affiliation:
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Department of Diagnostic Haematology, Royal Melbourne Hospital, VIC. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Biopsy Bone Marrow / pathology Bone Marrow Examination* Female Humans Male Medical Records Middle Aged Platelet Count Purpura, Thrombocytopenic, Idiopathic / blood, pathology* Reproducibility of Results Retrospective Studies Severity of Illness Index Victoria / epidemiology |
| Comments/Corrections | |
Comment In:
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Med J Aust. 1999 Mar 1;170(5):196-7
[PMID:
10092912
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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