| The diagnosis of Cushing's syndrome. | |
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MedLine Citation:
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PMID: 20821267 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spontaneous Cushing's syndrome is well known but unusual clinical disorder. Many of the clinical features (central weight gain, glucose intolerance, hypertension, muscle weakness) are seen in other common conditions. Recognition of patients with multiple features, features unusual for their age (i.e. early onset osteoporosis or hypertension), patients with features more specific to Cushing's syndrome (i.e. easy bruising, facial plethora, and violaceous striae), and patients with incidental adrenal mass or polycystic ovary syndrome should prompt an evaluation for cortisol excess. Late-night salivary cortisol, 1 mg overnight dexamethasone suppression testing, or 24 h urine free cortisol determination have excellent diagnostic characteristics and should be obtain in patients with suspected Cushing' syndrome. If this initial testing is abnormal, further evaluation should be directed by an endocrinologist experienced in the diagnosis and differential diagnosis of Cushing' syndrome. |
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Authors:
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Ty B Carroll; James W Findling |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Reviews in endocrine & metabolic disorders Volume: 11 ISSN: 1573-2606 ISO Abbreviation: Rev Endocr Metab Disord Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100940588 Medline TA: Rev Endocr Metab Disord Country: United States |
Other Details:
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Languages: eng Pagination: 147-53 Citation Subset: IM |
Affiliation:
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Endocrinology Center (TBC, JWF), Medical College of Wisconsin, W129 N7055 Northfield Drive Building A, Suite 203, Menomonee Falls, WI 53051, USA. tcarroll@mcw.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cushing Syndrome
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diagnosis* Humans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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