| The diagnosis of Cushing's syndrome using 131I-19-iodocholesterol uptake and adrenal imaging. | |
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MedLine Citation:
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PMID: 7438469 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Uptake measurements and visualization of the adrenal glands were performed using 131I-19-iodocholesterol in ten healthy subjects and fourteen patient suffering from Cushing's syndrome (nine hyperplasias and five adenomas). The normal range in healthy subjects (average uptake value +/- 2 SD) is 0.12-0.27% for both adrenals. In patients with Cushing's syndrome the uptake values ranged from 0.321 to 1.497%. Normal bilateral images were obtained in all the healthy subjects as well as in eight of the patients with hyperplasia, whilst the remaining patient with hyperplasia showed distinctly enlarged glands. In contrast, an image of the diseased side only was obtained in patients with adrenal adenomas. We conclude that radiocholesterol studies in Cushing's syndrome allow confirmation of the diagnosis, definition of the pathophysiologic type of disease and lateralization of adrenal adenomas. |
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Authors:
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D Ortega; M Foz; F M Doménech-Torné; J M Tresánchez |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical endocrinology Volume: 13 ISSN: 0300-0664 ISO Abbreviation: Clin. Endocrinol. (Oxf) Publication Date: 1980 Aug |
Date Detail:
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Created Date: 1981-02-24 Completed Date: 1981-02-24 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 145-9 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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19-Iodocholesterol
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diagnostic use*,
metabolism Adolescent Adrenal Glands / metabolism, radionuclide imaging* Adult Aged Cholesterol / analogs & derivatives* Cushing Syndrome / metabolism, radionuclide imaging* Female Humans Iodine Radioisotopes / diagnostic use* Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Iodine Radioisotopes; 30461-91-7/19-Iodocholesterol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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