Document Detail


The development of a seizure severity scale as an outcome measure in epilepsy.
MedLine Citation:
PMID:  1868824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In controlled trials of antiepileptic drugs (AEDs) seizure frequency is often the only variable considered. With little prospect of improving assessment of AEDs, using seizure counts as the only end-point, there is a need for the development of new outcome measures. Clinical experience indicates that seizure severity is equally important to the patient and, by preventing seizure spread, AEDs can influence seizure severity without necessarily reducing seizure frequency. A scale capable of measuring seizure severity and change of severity attributable to treatment could be a useful additional outcome measure. Such a scale should exhibit the basic properties of validity and reliability. An easily administrable 16-point scale, containing 2 subscales--perception of control and ictal/post-ictal effects--has been developed. This scale has been tested on a patient population (n = 159) representative of that seen in trials of novel AEDs. Using standardised statistical methods, the scale has been shown to be both reliable and valid.
Authors:
G A Baker; D F Smith; M Dewey; J Morrow; P M Crawford; D W Chadwick
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Epilepsy research     Volume:  8     ISSN:  0920-1211     ISO Abbreviation:  Epilepsy Res.     Publication Date:  1991 Apr 
Date Detail:
Created Date:  1991-09-19     Completed Date:  1991-09-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703089     Medline TA:  Epilepsy Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  245-51     Citation Subset:  IM    
Affiliation:
University Department of Neurosciences, Walton Hospital, Liverpool, U.K.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Analysis of Variance
Anticonvulsants / therapeutic use
Epilepsy / drug therapy,  physiopathology*
Female
Humans
Male
Middle Aged
Prognosis
Severity of Illness Index*
Chemical
Reg. No./Substance:
0/Anticonvulsants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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