Document Detail

The development of renal hypertension in the rat.
MedLine Citation:
PMID:  3575875     Owner:  NLM     Status:  MEDLINE    
The investigation was undertaken in an attempt to provide a more simple animal model for studying renal hypertension in the rat. Rats were surgically altered by two procedures, single nephrectomy and single nephrectomy plus encapsulation, the latter completed in a common operation. Systolic blood pressure was observed at various intervals of 14, 30, and 60 days. Systolic blood pressure was also observed at an 80 day interval in a control group. The results are as follows: Untreated Control - Systolic blood pressure was not significantly altered over an 80 day interval; Single Nephrectomy - Systolic blood pressure was not significantly altered at the 14, 30, or 60 day intervals (one animal died in this group immediately after surgery); Single Nephrectomy and Encapsulation - Of the 18 animals in this group 5 had significantly elevated systolic blood pressure by the 14 day interval, 1 became hypertensive by the 60 day interval, 6 showed no significant effect on systolic blood pressure, and 6 animals succumbed. Necropsies on the 6 animals which had no effect showed that the encapsulation procedure had failed.
P M Lemke; R F Gautieri
Related Documents :
19172455 - Effects of mistletoe (viscum album l., loranthaceae) extracts on arterial blood pressur...
6407335 - Central catecholamine depletion, vasopressin, and blood pressure in the doca/nacl rat.
2627695 - Hypotensive properties of antibodies directed against an endogenous pressor peptide iso...
19210395 - Cardiovascular instability induced by intracerebroventricular administration of vasopre...
594285 - Psychosocial stimuli and human plasma renin activity.
23091375 - Efficacy of percutaneous transluminal renal angioplasty with stent in elderly male pati...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  55     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-12     Completed Date:  1987-06-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-74     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Blood Pressure
Disease Models, Animal
Hypertension, Renal / physiopathology*
Rats, Inbred Strains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Steroid modulation of liver regeneration and hepatic microsomal enzymes in rats of either sex.
Next Document:  Effect of Fluosol-DA hemodilution on the kinetics of hepatically eliminated drugs.