Document Detail


The development of renal hypertension in the rat.
MedLine Citation:
PMID:  3575875     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The investigation was undertaken in an attempt to provide a more simple animal model for studying renal hypertension in the rat. Rats were surgically altered by two procedures, single nephrectomy and single nephrectomy plus encapsulation, the latter completed in a common operation. Systolic blood pressure was observed at various intervals of 14, 30, and 60 days. Systolic blood pressure was also observed at an 80 day interval in a control group. The results are as follows: Untreated Control - Systolic blood pressure was not significantly altered over an 80 day interval; Single Nephrectomy - Systolic blood pressure was not significantly altered at the 14, 30, or 60 day intervals (one animal died in this group immediately after surgery); Single Nephrectomy and Encapsulation - Of the 18 animals in this group 5 had significantly elevated systolic blood pressure by the 14 day interval, 1 became hypertensive by the 60 day interval, 6 showed no significant effect on systolic blood pressure, and 6 animals succumbed. Necropsies on the 6 animals which had no effect showed that the encapsulation procedure had failed.
Authors:
P M Lemke; R F Gautieri
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Research communications in chemical pathology and pharmacology     Volume:  55     ISSN:  0034-5164     ISO Abbreviation:  Res. Commun. Chem. Pathol. Pharmacol.     Publication Date:  1987 Mar 
Date Detail:
Created Date:  1987-06-12     Completed Date:  1987-06-12     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0244734     Medline TA:  Res Commun Chem Pathol Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  367-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure
Disease Models, Animal
Hypertension, Renal / physiopathology*
Male
Nephrectomy
Rats
Rats, Inbred Strains

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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