Document Detail


The development of the pulmonary surfactant system in California sea lions.
MedLine Citation:
PMID:  15964230     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary surfactant has previously been shown to change during development, both in composition and function. Adult pinnipeds, unlike adult terrestrial mammals, have an altered lung physiology to cope with the high pressures associated with deep diving. Here, we investigated how surfactant composition and function develop in California sea lions (Zalophus californianus). Phosphatidylinositol was the major anionic phospholipid in the newborn, whereas phosphatidylglycerol was increased in the adult. This increase in phosphatidylglycerol occurred at the expense of phosphatidylinositol and phosphatidylserine. There was a shift from long chain and polyunsaturated phospholipid molecular species in the newborn to shorter chain and mono- and disaturated molecular species in the adult. Cholesterol and SP-B concentrations were also higher in the adult. Adult surfactant could reach a lower equilibrium surface tension, but newborn surfactant could reach a lower minimum surface tension. The composition and function of surfactant from newborn California sea lions suggest that this age group is similar to terrestrial newborn mammals, whereas the adult has a "diving mammal" surfactant that can aid the lung during deep dives. The onset of diving is probably a trigger for surfactant development in these animals.
Authors:
Natalie J Miller; Anthony D Postle; Samuel Schürch; W Michael Schoel; Christopher B Daniels; Sandra Orgeig
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  141     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-07-18     Completed Date:  2005-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  191-9     Citation Subset:  IM    
Affiliation:
Environmental Biology, School of Earth and Environmental Sciences, Darling Building, University of Adelaide, North Tce, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Cholesterol / analysis
Enzyme-Linked Immunosorbent Assay
Female
Lung / metabolism
Male
Phospholipids / analysis
Pulmonary Surfactant-Associated Protein A / analysis
Pulmonary Surfactant-Associated Protein B / analysis
Pulmonary Surfactants / chemistry,  metabolism*
Sea Lions / physiology*
Spectrometry, Mass, Electrospray Ionization
Surface Tension
Chemical
Reg. No./Substance:
0/Phospholipids; 0/Pulmonary Surfactant-Associated Protein A; 0/Pulmonary Surfactant-Associated Protein B; 0/Pulmonary Surfactants; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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