Document Detail


The development of myelin-forming glia: studies with primary cell cultures and immortalized cell lines.
MedLine Citation:
PMID:  8087540     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The myelin-forming glial cells, oligodendrocytes and Schwann cells, undergo a sequence of maturation steps from precursor cell to mature myelinating cell. This includes migration from their site of generation to the axons they will myelinate. The recognition and interaction with the axons prior to the formation of compact myelin involve the interplay of a range of cell surface receptors and adhesion molecules, some of which have been defined. Signal transduction by such adhesion molecules may play a role in the recognition event. The generation of a range of immortalized cell lines and clones of oligodendroglial precursor cells and the analysis of their in vitro and in vivo properties have demonstrated the ability of these lines to recognize axons. They are providing useful tools to investigate the molecular basis of glia-neuron interactions.
Authors:
J Trotter
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Perspectives on developmental neurobiology     Volume:  1     ISSN:  1064-0517     ISO Abbreviation:  Perspect Dev Neurobiol     Publication Date:  1993  
Date Detail:
Created Date:  1994-10-19     Completed Date:  1994-10-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9417971     Medline TA:  Perspect Dev Neurobiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  149-54     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, University of Heidelberg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers
Cell Adhesion Molecules / metabolism
Cell Communication
Cell Differentiation
Cell Line
Cell Line, Transformed
Cell Movement
Cell Transformation, Viral
Cells, Cultured
Demyelinating Diseases / therapy
Genetic Vectors
Mice
Models, Biological
Myelin Sheath / physiology*
Nerve Tissue Proteins / metabolism
Oligodendroglia / cytology*
Rats
Retroviridae
Schwann Cells / cytology*,  transplantation
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cell Adhesion Molecules; 0/Nerve Tissue Proteins

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