Document Detail


The development of models for the evaluation of pulmonary drug disposition.
MedLine Citation:
PMID:  23294005     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: The process of drug disposition in the lung after pulmonary delivery is complex involving absorptive and non-absorptive mechanisms. The lung has also been suggested to be a trapping and metabolizing organ, especially after intravenous administration of drug. A key challenge is to define the most suitable models for the evaluation of pulmonary drug disposition.
AREAS COVERED: This review provides an overview of the anatomy and physiology of the lung and sites of action. The authors follow this with a description of the processes associated with pulmonary disposition (deposition, absorption, distribution, metabolism, and non-absorptive clearance). The article also summarizes and compares models and techniques for the assessment of drug disposition in the lung, in terms of characteristic features, advantages and disadvantages. Finally, the authors review pharmaceutical science implications of these findings.
EXPERT OPINION: In vivo models are preferred for studying drug deposition, absorption, disposition, and response in the lung. In vitro models may be useful in the initial screening for new compounds and in drug lead optimization. The labor-intensive isolated perfused lung models are most suitable for in-depth studies on drug pulmonary disposition for lead compounds. In the future, engineered lungs may become a more convenient means of evaluating drug disposition in the lung.
Authors:
Xin Liu; Lu Jin; John W Upham; Michael S Roberts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-08
Journal Detail:
Title:  Expert opinion on drug metabolism & toxicology     Volume:  9     ISSN:  1744-7607     ISO Abbreviation:  Expert Opin Drug Metab Toxicol     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-09-25     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  101228422     Medline TA:  Expert Opin Drug Metab Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  487-505     Citation Subset:  IM    
Affiliation:
University of Queensland, Princess Alexandra Hospital, School of Medicine, Therapeutics Research Centre, Woolloongabba, Brisbane, QLD 4102, Australia.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Administration, Inhalation
Administration, Intravenous
Animals
Cells, Cultured
Humans
Kinetics
Lung / drug effects*,  metabolism
Models, Biological
Pharmaceutical Preparations / administration & dosage*
Tissue Distribution / drug effects
Chemical
Reg. No./Substance:
0/Pharmaceutical Preparations

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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