Document Detail

The development of the method for the determination of terbinafine in cat's plasma and hair.
MedLine Citation:
PMID:  11005657     Owner:  NLM     Status:  MEDLINE    
Clinical investigations of terbinafine indicate its high treatment activity against infections by several dermatophytes. Its efficiency was tested also in the treatment of microsporosis in cats. The distribution of terbinafine in cat's plasma and hair is important for the identification of the drug efficiency. A fast and reliable reversed-phase high performance liquid chromatographic method with appropriate sample preparation has been developed. Reliability, good reproducibility and low detection limit (LOD 0.25 ng/ml) of the method enable determination of terbinafine in hair and also in plasma of cats infected with Microsporum canis treated by Lamisil tablets.
N Kozuh Erzen; J Kuzner; M Drobnic-Kossorok
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  440     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-02     Completed Date:  2001-02-01     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  R168-70     Citation Subset:  IM    
Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, University of Ljubljana, Slovenia.
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MeSH Terms
Chromatography, High Pressure Liquid / methods*
Hair / chemistry*
Naphthalenes / analysis*,  blood*
Reproducibility of Results
Reg. No./Substance:
0/Naphthalenes; 91161-71-6/terbinafine

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