Document Detail


The development of manifest psoriatic lesions is linked with the appearance of ICAM-1 positivity on keratinocytes.
MedLine Citation:
PMID:  7763088     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of psoriatic lesions was studied in 36 psoriatic patients using the Koebner reaction induced by tape stripping. Two biopsies per patient were taken from non-lesional psoriatic skin before, and 6 h, 2 days, 7 days, 14 days and 21 days after tape stripping. Alterations in HLA-DR, ICAM-1, Ki-67 and FXIIIa positivities in both the dermis and the epidermis were estimated using immunohistochemical methods. A double staining for CD4+ and CD8+ T cells was also carried out to show their possible Ki-67 positivity. Results were compared with those from lesional (mature plaque) and non-lesional psoriatic skin, and control skin. Of the 36 patients, 9 were Koebner-positive. The most important finding in Koebner-positive psoriatic skin was the appearance of ICAM-1 positivity on epidermal keratinocytes simultaneously with the clinically observed lesion on day 7. The number of FXIIIa+ dendrocytes in the dermis was quite constant, and increased in mature psoriatic lesions only. The number of active HLA-DR+ immunocompetent cells increased in developing psoriatic lesions, being highest in mature lesions, but no Ki-67 positivity was detected in epidermal or dermal T cells in the psoriatic specimens. Based on these results, it is concluded that T cells divide and are activated extracutaneously in psoriasis, and also that ICAM-1/LFA-1 interactions are important in the recruitment of inflammatory cells and in controlling the effector cell functions.
Authors:
K Paukkonen; A Naukkarinen; M Horsmanheimo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of dermatological research     Volume:  287     ISSN:  0340-3696     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  1995  
Date Detail:
Created Date:  1995-06-26     Completed Date:  1995-06-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  165-70     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Kuopio University Hospital, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / analysis
Biopsy
Case-Control Studies
Epidermis / cytology,  immunology,  pathology
Female
HLA-DR Antigens / analysis
Humans
Intercellular Adhesion Molecule-1 / analysis*
Keratinocytes / cytology,  immunology,  pathology*
Ki-67 Antigen
Male
Middle Aged
Neoplasm Proteins / analysis
Nuclear Proteins / analysis
Psoriasis / immunology,  pathology*
Reference Values
T-Lymphocytes / immunology,  pathology
Transglutaminases / analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/HLA-DR Antigens; 0/Ki-67 Antigen; 0/Neoplasm Proteins; 0/Nuclear Proteins; 126547-89-5/Intercellular Adhesion Molecule-1; EC 2.3.2.13/Transglutaminases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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