| The development of the human tonsilla palatina. | |
| | |
MedLine Citation:
|
PMID: 6981458 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Tonsils of human fetuses at the 8th to the 28th gestational week (g.w.) were investigated by electron microscopy, enzyme histochemistry, and immunohistochemistry on cryostat sections. The development of the tonsilla palatina starts during the 14th g.w. when the mesenchyme underlying the mucous membrane of the tonsillar cavity becomes invaded by mononuclear wandering cells. In fetuses of about the 16th g.w. epithelial crypts grow down into the connective tissue and are infiltrated by T-lymphocytes. At the same time, precursors of interdigitating cells (IDC) can be identified among the epithelial cells. Frequently, lymphocytes and IDC-like cells are in close contact. From these findings it is concluded that the infiltrated crypt epithelium in the human tonsilla palatina represents a T-cell region. Primary follicles develop in earlier fetal stages than in all other secondary lymphoid organs. They contain precursors of dendritic reticulum cells and lymphoid cells that belong to the B-cell line. These primary follicles may be considered as the first assemblage of B-cell regions in human fetal lymphoid tissue. The present findings indicate that the formation of different stationary elements during the development of B-cell regions and T-cell regions is an important factor for the homing and antigen-dependent maturation of different subpopulations of immunocompetent lymphoid cells. |
| | |
Authors:
|
B von Gaudecker; H K Müller-Hermelink |
Related Documents
:
|
916748 - Neural and endocrine control systems acting on the population kinetics of the intestina... 630578 - Differential radiation response amongst proliferating epithelial cells. 12165508 - Selective adherence of iga to murine peyer's patch m cells: evidence for a novel iga re... 7309898 - Measurements of intestinal villi non-specific and ulcer-associated duodenitis-correlati... 17465508 - Reversal of multidrug resistance in vincristine-resistant human gastric cancer cell lin... 21636528 - Dnmt1 deficiency triggers mismatch repair defects in human cells through depletion of r... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Cell and tissue research Volume: 224 ISSN: 0302-766X ISO Abbreviation: Cell Tissue Res. Publication Date: 1982 |
Date Detail:
|
Created Date: 1982-12-02 Completed Date: 1982-12-02 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0417625 Medline TA: Cell Tissue Res Country: GERMANY, WEST |
Other Details:
|
Languages: eng Pagination: 579-600 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
B-Lymphocytes
/
cytology Cell Differentiation Cell Nucleus / ultrastructure Connective Tissue / embryology Cytoplasm / ultrastructure Epithelium / ultrastructure Gestational Age Humans Macrophages / ultrastructure Microscopy, Electron Monocytes / ultrastructure Organoids / ultrastructure Palatine Tonsil / embryology*, ultrastructure T-Lymphocytes / cytology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Chromosomes and causation of human cancer and leukemia. XLVIII. T-cell acute leukemia in ataxia tela...
Next Document: The replication of bacteriophage f1: gene V protein regulates the synthesis of gene II protein.