Document Detail

The development of the fetal eye: in utero ultrasonographic measurements of the vitreous and lens.
MedLine Citation:
PMID:  7784367     Owner:  NLM     Status:  MEDLINE    
Our objective was to establish nomograms for fetal eye measurements from 12 weeks' gestation by using transvaginal and transabdominal high-resolution ultrasound techniques. A prospective cross-sectional study was performed on 450 normal singleton pregnancies between 12 and 37 weeks' gestation. Vitreous and lens circumferences were measured by transvaginal ultrasonography until 17 weeks, and by abdominal ultrasound between 18 and 37 weeks' gestation. Regression analyses were used to create nomograms, and several transformations were done to obtain linearity. Eye measurements of 12 fetuses at risk for ocular disturbances were plotted on the constructed nomograms. Linear relationships were fitted between vitreous (r2 = 0.79) and lens (r2 = 0.88) circumferences and gestational age. In addition, there was a significant correlation between these measurements and the biparietal diameter. Data of the fetuses at risk showed that disturbances in ocular growth were associated mainly with abnormal cerebral development. These normative data may be helpful in the prenatal diagnosis of suspected congenital syndromes that include, among their manifestations, ocular growth disturbances such as microphthalmos and anophthalmos.
R Achiron; Z Gottlieb; Y Yaron; M Gabbay; U Gabbay; S Lipitz; S Mashiach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prenatal diagnosis     Volume:  15     ISSN:  0197-3851     ISO Abbreviation:  Prenat. Diagn.     Publication Date:  1995 Feb 
Date Detail:
Created Date:  1995-07-20     Completed Date:  1995-07-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8106540     Medline TA:  Prenat Diagn     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  155-60     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Israel.
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MeSH Terms
Cross-Sectional Studies
Eye / embryology*,  ultrasonography
Fetal Organ Maturity / genetics
Lens, Crystalline / embryology*,  ultrasonography
Prospective Studies
Regression Analysis
Ultrasonography, Prenatal*
Vitreous Body / embryology*,  ultrasonography

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